参麦对老年2型糖尿病患者胰岛功能及微循环的影响

Effect of Shenmai injection on pancreas islet function and microcirculation state of elderly patients with type 2 diabetes

目的：探讨参麦对老年2型糖尿病患者胰岛功能及微循环状态的影响。方法：选择2011年1月~2014年9月60例老年2型糖尿病患者为研究对象,按照随机数字表法分为观察组、对照组各30例。对照组给予常规西医治疗;观察组在对照组基础上,给予参麦注射液治疗。检测治疗前、治疗后1周、治疗后3周C肽、胰岛素分泌指数（HOMAβ）、胰岛素抵抗指数（HOMA IR）及糖化血红蛋白（HbA1c）、输入枝管径、输出枝管径、襻顶血管直径、管襻畸形数、管襻积分、管周状态积分、流态积分、总积分等指标。结果：治疗后1周、治疗后3周观察组血清C肽、HOMAβ水平明显高于同期对照组,血清HOMA IR、HbA1c水平明显低于同期对照组（P〈0.05）;治疗后1周、治疗后3周观察组输入枝管径、输出枝管径、襻顶血管直径明显高于同期对照组,管襻畸形数明显低于同期对照组（P〈0.05）;治疗后1周、治疗后3周观察组管襻积分、管周状态积分、流态积分、总积分明显低于同期对照组（P〈0.05）。结论：采用参麦注射液治疗2型糖尿病,可以有效改善患者胰岛功能及微循环功能,进而降低相关并发症,并有效改善患者病情和预后。

Objective：To study effect of Shenmai injection on pancreas islet function and microcirculation state of elderly patients with type 2diabetes.Methods：Between January 2011 and September 2014,60 cases of elderly patients with type 2diabetes were selected as the research object,and 60 patients according to random number table method were randomly divided into observation group and control group with 30 cases in each group.Thirty cases in control group were given conventional western medicine treatment;and 30 cases in observation group were given Shenmai injection treatment based on conventional western medicine treatment.C peptide and insulin secretion index（HOMA beta）,insulin resistance index（HOMA IR）and glycosylated hemoglobin（HbA1c）,input and output branch pipe diameter,loop of blood vessel diameter,number of loop deformity,pipe loop integral,peripheral pipe points,flow regime score,total integral were tested 1week,3weeks before and after treatment.Results：3weeks,1week after treatment,serum c-peptide,HOMA beta levels in the observation group were significantly higher than these of the control group,and serum HOMA IR,HbA1 clevels were significantly lower than the control group（P〈0.05）;3weeks,1week after treatment,output and input branch pipe diameter,branch pipe diameter,loop blood vessel diameter of treatment group were significantly higher than control group,and the number of loop deformity was significantly lower than the control group（P〈0.05）;3weeks,1week after treatment,in pipe loop integral,peripheral pipe points,flow regime score,total integral of treatment group were significantly lower than these of control group（P〈0.05）.Conclusions：Shenmai injection in the treatment of type 2diabetes,can effectively improve the function of pancreatic islet and microcirculation,thus reduce the related complications,and effectively improve disease condition and prognosis.