聚乳酸-羟基乙酸纳米粒及其修饰应用

Modification and Application of PLGA-based Nanoparticles

笔者就聚乳酸-羟基乙酸(PLGA)纳米粒及其修饰手段和应用情况进行综述。根据国外文献报道,对近年来聚乳酸-羟基乙酸纳米粒的制备及其修饰作用和应用的研究进行分析和归纳。聚乳酸-羟基乙酸是缓控释可生物降解微粒制备中应用最多的载体材料之一。本篇综述重点关注聚乳酸-羟基乙酸纳米粒的制备及修饰。制备方法主要包括乳化法、界面沉积法、自乳化溶剂扩散法、溶剂注入法以及超临界流体抗溶剂法。修饰方法主要为共价交联、静电吸附和疏水作用力。修饰的目的主要可以应用于优化包囊参数、调节释放、提高细胞摄取和靶向特定的组织或细胞。

This review provided the research progresses of the strategies of the modification and application of poly （laetic-co-glycolic acid, PLGA） nanoparticles. The preparation and modification methods of PLGA nanoparticles and their application according to the reported foreign literature were analysed and summaried. PLGA is a biodegradable and biocompatible polymer which is one of the most widely used materials in preparation of sustained and controlled microparticles as drug vectors. This review focuses on the methods of modified nanoparticles and the advantages. Emulsification method, nanoprecipitation, emulsification solvent diffusion, solvent injection method and supercritical anti-solvent technique are the main five preparation methods of PLGA nanoparticles. The strategies of modifition include covalent cross-link, electrostatic interaction and hydrophobic interaction. The applications of modified nanoparticles to the optimal formulation, sustained release profile, improved cellular uptake, and targeting to specific organs or cells are introduced.