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RKIP低表达与食管鳞状细胞癌浸润、转移及预后的相关性 被引量：1

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摘要 目的探讨RKIP表达与食管鳞状细胞癌浸润、转移及预后的关系。方法采用免疫组化法检测87例食管鳞状细胞癌及癌旁组织中RKIP的表达;采用甲基化特异性PCR(methylation-specific PCR,MSP)技术检测食管鳞状细胞癌及癌旁组织中RKIP的甲基化情况;采用Kaplan-Meier法评估食管鳞状细胞癌患者术后5年生存率;采用Cox比例风险模型分析RKIP对食管鳞状细胞癌患者预后的影响。结果食管鳞状细胞癌中RKIP的阳性率低于癌旁组织(P<0.05),RKIP表达与食管鳞状细胞癌的分化程度和淋巴结转移相关(P<0.05);食管鳞状细胞癌中RKIP基因启动子甲基化阳性率高于癌旁组织(P<0.05);RKIP低表达与RKIP基因启动子甲基化相关(P<0.05);RKIP蛋白阳性组患者5年生存率明显高于RKIP蛋白阴性组(P<0.01);RKIP表达是食管鳞状细胞癌的独立预后因素。结论食管鳞状细胞癌RKIP基因启动子甲基化是导致RKIP低表达的原因之一,RKIP低表达与食管鳞状细胞癌的浸润、转移及预后有关,有望成为食管鳞状细胞癌分子治疗的靶点。
作者 张付美 李冬霞 朱芳恒 叶历 秦栓梅
机构地区 河南省新乡市中心医院病理科 新乡医学院基础医学院
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2015年第8期911-913,共3页 Chinese Journal of Clinical and Experimental Pathology
关键词 食管肿瘤 鳞状细胞癌 RKIP 预后 浸润 转移
分类号 R735.1 [医药卫生—肿瘤]
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参考文献10

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二级参考文献21

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临床与实验病理学杂志
2015年 第8期

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