舒利迭联合噻托溴铵对稳定期中重度慢性阻塞性肺疾病患者肺功能的影响

The impact on pulmonary function of seretide combined with tiotropium bromide in patients with moderate to severe stable chronic obstructive pulmonary disease

目的探讨舒利迭联合思力华对稳定期中重度慢性阻塞性肺疾病患者肺功能的影响。方法选择2013年1月~2014年1月在我院治疗的稳定期中重度慢性阻塞性肺疾病患者80例为研究对象,随机分为研究组和对照组各40例。对照组予思力华（噻托溴铵粉吸入剂）18μg/次,1次/d;研究组加用舒利迭（沙美特罗替卡松粉吸入剂）吸入,1吸/次,每日2次;观察并比较：两组临床治疗效果;两组患者治疗前后两SGRQ评分;两组肺功能指标FEV1、FEV1/FVC。结果研究组联合治疗后的总有效率达90.0%（36/40）,与对照组治疗后的总有效率70.0%（28/40）相比,差异有统计学意义（P〈0.05）。治疗后3个月,研究组患者SGRQ评分中临床、活动和影响三部分分别显著低于对照组（t=5.231、4.623、4.865,P〈0.05）。治疗后,研究组肺功能指标FEV1、FEV1/FVC分别高于治疗前,也显著高于对照组（P〈0.01）。结论舒利迭联合思力华联合应用于稳定期中重度慢性阻塞性肺疾病患者可以提高疗效,改善患者的生活质量,提高患者的肺功能。

Objective To investigate the impact on pulmonary function of Seretide combined with tiotropium bromide in patients with moderate to severe stable chronic obstructive pulmonary disease. Methods From January 2013 to January 2014 in our hospital, 80 cases of patients, were randomly divided into study group and control group of 40 cases. The control group was treated by Si Lihua（Tiotropium Bromide Powder for Inhalation） 18 μg/times, 1 time/d; study group was treated with Seretide（Shah Mette Lo fluticasone inhalation）, 1 suction/time, 2 times/d; The clinical therapeutic effect, the SGRQ scores,the FEV1, FEV1/FVC of lung function index were observed and compared before and after treatment between two groups. Results The total effective rate of combined treatment group after treatment was 90.0% （36/40）, and control group was 70.0% （28/40）,the difference was ,statistically significant （P〈0.05）. After treatment 3 months,the SGRQ score in clinical,activity and effects of study group were significantly lower than the control group,the differences were significant between two groups（t=5.231,4.623,4.865,P〈0.05）. After treatment,the FEV1, FEV1/FVC of study group were higher than those before treatment,was significantly higher than that in control group （P〈0.01）. Conclusion Seretide combined with tiotropium bromide in patients with severe chronic obstructive pulmonary disease can improve the curative effect, improve the quality of life of patients, improve the patient＇s lung function.