牛蒡子苷元注射液对SD大鼠急性毒性研究

Study on Acute Toxicity of Arctigenin Injection in SD Rats

目的通过上下法(UDP)观察牛蒡子苷元注射液大鼠静脉注射及皮下注射毒性反应。方法 UDP试验分静脉注射和皮下注射两组,根据AOT425 StatPgm设定程序进行试验。健康SD大鼠40只,各组20只。结果静脉注射LD_(50)为8.9 mg·kg^(-1),95%置信区间6.6~17.5 g·kg^(-1),皮下注射LD_(50)为227.3 mg·kg^(-1),95%置信区间166.3~348 mg·kg^(-1)。结论牛蒡子苷元注射液静脉注射毒性较大,皮下注射较为安全。

Objective To study the acute toxicity of arctigenin injection in rats by Up-and-Down Procedure（UDP）. Methods The UDP test includes intravenous injection group and subcutaneous injection group, according to the AOT425 StatPgm administration. 40 healthy SD rats were divided into two groups, 20 each. Results LD50 of intra-venous injection group is 8.9 mg·kg -1, the 95% confidence interval is 6.6-17.5 mg·kg -1. LD50 of subcutaneous injection group is 227.3 mg·kg -1, the 95% confidence interval is 166.3-348 mg·kg -1. Conclusion In this study, arctigenin intravenous injection has greater toxicity, subcutaneous injection is relatively safe.