注射用双参粉针体内药代动力学研究

目的:建立丹参酚酸体内样品的测定方法,并比较其在单方和复方制剂中的药动学差异。方法:采用高效液相法,分别测定大鼠给予单方和复方制剂后的血浆样品。结果:采用DAS软件计算得到了药代动力学参数。结论:复方制剂中各丹参酚酸的半衰期明显延长,血药浓度的持续时间较单独使用延长,推测复方制剂中西洋参二醇组皂苷的存在可以使丹参酚酸更好地发挥治疗作用。

Objective： To establish a method for the determination of salvianolic acids in rats＇ plasma, and compare the results of compound and single prescription. Methods： The HPLC system has been used to determine plasma samples of rats after injection. Results： Pharmacokinetic parameters had been obtained. Conclusion： The half life of salvianolic acids was longer in compound prescription; blood concentration last longer. It infers that the compound prescription has better therapeutic effect than single.