一种异吲哚衍生物的合成与晶体结构

Synthesis and Crystal Structure of a Novel Isoindole Derivatives

以环辛烯、对甲基苯胺、N-溴代丁二酰亚胺(NBS)、丙烯酸、五氯化磷为初始原料合成N-丙烯酰基-N-(2-环辛烯)对甲基苯胺,主要研究了钯催化下该底物与4-溴-1,2-亚甲二氧基苯的C-H活化Domino环化反应。在温和条件下高效、高选择性一锅法合成了一种异吲哚衍生物产率为70%。通过IR,1HNMR,13CNMR,MS对目标产物的结构进行了表征,并用X-射线单晶衍射仪测得其晶体结构。

（Z） - N - （ cyclooct - 2 - enyl） - N - p - tolylacrylamide was synthesized by cyclooctene, 4 - Toluidine, NBS, acrylic acid and PC15. Then this paper focused on the Pd - catalyzed Domino[ 15 ] cyclization of the substrate with 4 - Bromo - 1, 2- （Methylenedioxy） benzene via C -H activation. A novel isoindole derivatives was prepared through one- pot method with high effectively and regioseleetivity under mild condition. The yield of the reaction is about 70%. The structure of the compound was confirmed by IR, 1HNMR, 13CNMR, MS and X- ray diffraction.