分子印迹聚合物在傅克酰基化反应中的底物识别性和区位选择性

The Capacity of Substrate Recognition and Regioselectivity of Molecular Imprinting Polymer in the Friedel-Crafts Acylation

采用分子印迹技术,以2-乙酰基环己酮与Co(Ⅱ)的配合物为模板,合成了对苯甲醚乙酰化反应的邻位取代产物有一定识别性能的钴配位分子印迹聚合物(Co(Ⅱ)-MIP).采用FT-IR,N2吸附-脱附和SEM等分析方法对分子印迹聚合物进行了表征.并将该印迹聚合物应用于苯甲醚酰基化反应中,考察了对苯甲醚酰基化反应区位选择性能力,结果表明Co(Ⅱ)-MIP的印迹空腔具有特定的空间立体结构和结合位点,表现出一定的酰基化试剂识别性和邻位酰基化区位选择性,提高了苯甲醚邻位乙酰化产物的产率.

The metal molecular imprinting polymer （Co（ Ⅱ ）-MIP） was prepared by the molecular imprinting of 2-acetylcyclohexanone and cobalt （ Ⅱ ） ion precursor, and was well characterized by the FT-IR, N2 adsorption- desorption and SEM techniques. The template-imprinted memory within the polymer induced certain substrate se- lectivity and regioselectivity in catalyzing the anisole acetylation reaction using acetyl chloride as an acetylation rea- gent. It significantly enhanced the product of o-methoxyacetophenone as compared with non-imDrinted Polymer.