新生儿病房真菌感染菌种分布分析

The Species Distribution of Fungal Infections in Neonatal Ward

目的探讨新生儿病房的真菌种类及耐药性。方法回顾性分析我院2008年10月至2014年6月新生儿病房真菌培养的阳性结果,并与同期儿科病房的阳性结果比较。结果新生儿病房共获得真菌34株,标本来源前四位分别是痰液21例(61.8%),血液4例(11.8%),脑脊液3例(8.8%),气管导管3例(8.8%);按菌种分前三位分别是白色假丝酵母菌23株(69.70%),近平滑假丝酵母菌5株(15.15%),光滑假丝酵母菌4株(12.12%)。其他儿科病房培养阳性的真菌为143株。标本来源前四位分别为痰液84例(58.7%),血液/骨髓20例(14%),大便11例(7.7%),脑脊液/无菌体液11例(7.7%)。按菌种分前三位分别为白色假丝酵母菌76株(58.91%),光滑假丝酵母菌21株(16.28%),近平滑假丝酵母菌14株(10.85%)。新生儿病房中最常见的白色假丝酵母菌对氟康唑耐药率较低。结论新生儿病房真菌感染第一位的是白色假丝酵母菌,对氟康唑耐药率较低。

Objective To investigate the fungal species and antibiotics resistance in neonatal ward. Methods A retro- spective analysis of the positive fungal culture results was made in the neonatal ward of West China Second University Hospital from October 2008 to June 2014, and the results were compared with the other pediatric wards. Results There were 34 strains of fungi in neonatal ward, the most common specimen source was sputum （21 cases, 61.8% ）, next was blood （4 cases, 11.8% ）, cere- brospinal fluid （3 cases, 8. 8% ） , and tracheal catheter tip （3 cases, 8. 8% ）, respectively. The most common species was Candi- da albicans （23 strains, 69.70% ）, next was Asandida parapsilosis （5 strains, 15. 15% ）,and Candida glabrata （4 strains, 12. 12% ）, respectively. Other pediatric wards had 143 strains of fungai, the most common specimen sourcewas sputum （ 84 ca- ses, 58.7% ）, next was blood or bone marrow （20 cases, 14% ）, the stool （11 cases, 7.7% ）, and CSF or sterile body fluid （11 cases, 7.7% ）, respectively. The most common species was Candida albicans （76 strains,58.91% ）, secondly was Candida glabrata （21 strains,16. 28% ）, and Candida parapsilosis （14 strains, 10. 85% ）, respectively. In neonatal ward, the most com- mon species was Candida alhicans, and the total rate of susceptible to fluconazolewas excellent. Conclusion The most common neonatal fungal infection is Candida alhicans, and the fluconazole resistance rate is low.