EBV感染患者心血管疾病发病的临床分析

Clinical Analysis of Cardiovascular Disease in Patients with EBV Infection

目的分析457例EBV(Epstein-Barr virus infection,EBV)不同感染类型的患者的CVD(Cardiovascular disease,CVD)发病以及与CVD发病相关的炎症因子表达水平,探讨EBV不同感染类型的患者与CVD发生存在的相关性。方法回顾性分析457例EBV的患者(IM、CAEBV,EBV-HLH)CVD发生率,及EBV-DNA、D-Dimer、BNP、IL-6的峰值表达水平与CVD发生的相关性。结果 EBV感染不同类型患者CVD的发生率明显不同,其中EBV-HLH最高,IM最低;在IM、CAEBV、EBV-HLH组内CVD发生和未发生组中相关指标BNP、D-Dimer、IL-6表达差异有统计学意义(P<0.01),而CVD发生患者中随着EBV感染发病的严重BNP、D-Dimer、IL-6表达明显增高;EBV感染诱发的CVD患者中BNP表达水平与D-Dimer和IL-6呈正相关,其中D-Dimer与BNP相关性最高。结论 EBV感染可能继发心血管疾病的风险,且随着EBV感染程度的增加,风险越大;CVD实验室相关检测因子的相关性统计分析发现,EBV感染及感染程度可能通过影响炎症因和血栓形成相关因子的表达水平进而促成心血管疾病的发生。

Objective To analyze association between CVD （ Cardiovascular diseases） and levels of inflammatory factors in 457 patients of EBV （ Epstein - Barr virus get infection, and EBV） different types of infection. Methods The CVD rate was retrospectively analyzed in and 457 patients with EBV （ IM, CAEBV, EBV - HLH） and the correlation between peak expression levels of EBV DNA, D-Dimer, BNP, IL-6 and the occurrence of CVD. Results The incidence rate of EBV infection in patients with different types of CVD were obviously different, EBV-HLH was highest while IM lowest, CAEBV, EBV in IM-HLH CVD not happening within group BNP, D-Dimer in relevant indicators were differentially expressed, IL-6 （ P 〈 0. 01 ）, and CVD in patients with EBV infection incidence of severe BNP, D-Dimer, IL-6 expression inere^ed obviously; EBV infection induced the expression of BNP levels in patients with CVD and D-Dimer and IL-6 were positively correlated, the D-Dimer with highest correlation with the BNP. Conclusion Increased EBV infection could lead to the risk of cardioascular disease, and CVD factors associated laboratory related statistical analysis found that EBV infection, and the degree of infection may be affected by the expression level of inflamma- tion and thrombosis related factors, in turn, contribute to the occurrence of cardiovascular disease.