不同维持剂量咖啡因治疗早产儿呼吸暂停的疗效观察

Different Maintenance Dose plus Caffeine Curative Effect Observation of Treatment of Premature Infant Apnea

目的探讨不同维持剂量咖啡因治疗早产儿呼吸暂停的疗效。方法将我院NICU 2012年1月至2014年11月3年间收治并符合条件的77例出现呼吸暂停的早产儿随机分为3组,A组23例,B组28例,C组26例,三组均在常规治疗(按摩脊背,弹足底,俯卧位,若不能缓解并出现发绀时予以复苏囊正压给氧)的基础上,使用咖啡因治疗,先给予20mg/kg负荷量,24h后三组分别给予5mg/kg、10mg/kg、15mg/kg维持。结果 B、C两组发生呼吸暂停的次数明显减少,治疗时间较A组明显缩短,停药时间提前,A、B两组相比,A、C两组相比差异有统计学意义(P<0.05);B、C两组相比差异无统计学意义(P>0.05)。结论早产儿呼吸暂停使用咖啡因治疗先用20mg/kg负荷量后,维持量用10mg/kg效果明显。

Objective To explore the curative effect of different maintenance dose plus caffeine for the treatment of pre- mature infant apnea. Methods From January 2012 - November 2014 treated 80 cases in NICU with apnea of premature infants were randomly divided into 3 groups, group A （23 cases）, group B （28 cases）, group C （26 cases）, three groups were received routine therapy （ massage back, playing A foot, the prone position, if cant ease and Cyanosis when recovery capsule positive pres- sure to oxygen）, on the basis of using caffeine treatment, providing first 20 mg,/kg body weight load. 24 hours later the three groups were given 5 mg/kg, 10 mg/kg, and 15 mg/kg. Results The rate of apnea was significantly reduce in group B and C and the treatment time was shortened obviously compared with group A. A, B, compared two groups A and C was statistically significant difference in two groups, P 〈 0. 05 ; B, C, there was no statistically significant difference in two groups（P 〉 0. 05 ）. Conclusion The premature infant apnea using caffeine after treatment with 20 mg/kg load first, maintain the quantity with 10 mg/kg body weight.