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抗病毒治疗对慢性乙型肝炎患者调节性T细胞影响的研究进展 被引量:2

Research progress of antiviral therapy influencing on regulatory T cell in patients with chronic hepatitis B
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摘要 慢性乙型肝炎患者抗病毒治疗在抑制病毒复制的同时也影响机体免疫功能。调节性T细胞为体内具有免疫调节功能的T细胞亚群,能抑制HBV感染者特异性T细胞反应。研究慢性乙型肝炎患者抗病毒治疗对调节性T细胞数量及功能的影响,可以为探索更理想的免疫学指标来评价抗病毒应答反应,治疗效果,预测治疗终点、停药后复发,疾病预后等打下基础,也可能为慢性乙型肝炎患者制订更优化的抗病毒治疗策略确定方向。 Antiviral therapy inhibits viral replication and also has some influence on body′s immunity in patients with chronic hepatitis B.Regulatory T cell,a subset of T cells,has an immunomodulatory function in vivo and can inhibit specific T cell response in HBV infection patients.Study of antiviral therapy influencing on amount of regulatory T cell and its function in patients with chronic hepatitis B can lay foundations for probing into more ideal immunological indicators to assess the anti-viral responses,therapeutic efficacy,predict the termination of treatment and recurrence after ceasing medication,disease prognosis,and may also point out the direction for developing more optimal strategies of antiviral treatment in patients with chronic hepatitis B.
出处 《中国当代医药》 2015年第23期15-18,共4页 China Modern Medicine
关键词 慢性乙型肝炎 抗病毒治疗 调节性T细胞 Chronic hepatitis B Antiviral therapy Regulatory T cell
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二级参考文献15

  • 1闫涛,王慧芬,季伟,张爱民,张政,张辉,王福生.干扰素α治疗慢性乙型肝炎过程中外周血树突状细胞亚群的变化及疗效关系[J].中华医学杂志,2005,85(17):1177-1181. 被引量:14
  • 2Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. 42 Dongsi Xidajie,Beijing 100710,China.慢性乙型肝炎防治指南[J].中华肝脏病杂志,2005,13(12):881-891. 被引量:1931
  • 3福军亮,徐东平,施明,张辉,金磊,汤紫荣,王福生.乙型肝炎患者外周血CD_4^+ CD_(25)^+调节性T细胞表型与功能分析[J].中华内科杂志,2006,45(8):642-645. 被引量:34
  • 4Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science, 2003, 299:1057- 1061.
  • 5Xu D, Fu J, Jin L, et al. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol, 2006, 177: 739-747.
  • 6Peng G, Li S, Wu W, et al. Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Immunology, 2008, 123: 57-65.
  • 7Stoop JN, van der Molen RG, Baan CC, et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology, 2005, 41: 771-778.
  • 8Baecher-Atlan C, Brown JA, Freeman GJ, et al. CD4+CD25high regulatory cells in human peripheral blood. J Immunol, 2001, 167: 1245-1253.
  • 9Bertoletti A, Gehring AJ. The immune response during hepatitis B virus infection. J Gen Virol, 2006, 87 (Pt 6): 1439-1449.
  • 10Franzese O, Kennedy PT, Gehring A J, et al. Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J Virol, 2005, 79: 3322-3328.

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