术前用右美托咪定对老年患者前列腺术后早期认知功能的影响

Influence of preoperative application of dexmedetomidine on postoperative early cognitive dysfunction for elderly patients after prostate purgery

目的 探讨术前使用右美托咪定对老年前列腺术后早期认知功能的影响。方法 选取本院2013年10月-2014年12月收治的64例老年前列腺患者作为研究对象,随机分成实验组和对照组,各32例。实验组在老年前列腺患者进行手术前泵注右美托咪定,对照组泵注等量的生理食盐水,比较两组的MMSE评分、术后认知功能障碍发生率及MAP和HR水平。结果 实验组术后5 h和1 d的MMSE评分显著高于对照组,差异有统计学意义（P〈0.05）。实验组的术后认知功能障碍发生率显著低于对照组,差异有统计学意义（P〈0.05）。实验组术后的MAP、HR水平显著低于对照组,差异有统计学意义（P〈0.05）。结论 在老年患者手术前使用右美托咪定,可以有效降低术后认知功能障碍发生率。

Objective To explore the influence of preoperative application of dexmedetomidine on early postoperative cognitive dysfunction（POCD） for elderly patients after prostate surgery. Methods 64 elderly patients with prostate disease in our hospital from October 2013 to December 2014 were selected and randomly divided into the experiment group and the control group,32 cases in each group.The experiment group was pumped with dexmedetomidine before surgery for elderly patients with prostate disease,the control group was pumped with the equal amount of normal saline.The score of MMSE,the incidence rate of POCD,the level of MAP and HR in two groups was compared. Results The score of MMSE after operation at 5 hours and 1 day in the experiment group was higher than that in the control group,with significant difference（P 0.05）.The incidence rate of POCD in the experiment group was lower than that in the control group,with significant difference（P 0.05）.The level of MAP and HR in the experiment group was lower than that in the control group,with significant difference（P〈0.05）. Conclusion Dexmedetomidine applied before surgery for elderly patients can effective reduce the incidence rate of POCD.