尼可地尔治疗心绞痛的临床效果分析

Analysis of clinical curative effects of nicorandil in the treatment of angina

目的探讨尼可地尔治疗心绞痛的临床疗效,为临床治疗提供依据。方法选取2011年9月-2014年2月我院收治的心绞痛患者146例,随机分为对照组和治疗组,各73例,对照组在常规治疗的基础上应用单硝酸异山梨酯注射液治疗,治疗组在常规治疗的基础上应用尼可地尔治疗,观察比较30 d后的疗效。结果治疗组显效31例（42.46%）,有效37例（50.68%）,无效5例（6.85%）,总有效率为93.15%。对照组显效20例（27.40%）,有效35例（47.94%）,无效18例（24.66%）,总有效率为75.34%。两组比较,差异有统计学意义（χ^2=5.235,P=0.043）。结论在常规治疗的基础上应用尼可地尔治疗心绞痛,不仅可以提高治疗效果,降低不良反应发生率,而且可以明显改善患者的生活质量,减轻患者痛苦,降低复发率,值得临床推广应用。

Objective To discuss the clinical curative effects of nicorandil in the treatment of angina,and to provide evidence for clinical treatment. Methods 146 patients with angina who were admitted and treated in our hospital from September 2011 to February 2014 were selected.They were randomly assigned to control group and treatment group,with73 patients in each group.The control group was given the treatment of isosorbide mononitrate injection on the basis of regular treatment,and the treatment group was given the treatment of nicorandil on the basis of regular treatment.The curative effects was compared and observed respectively after 30 days. Results In the treatment group,31 patients were significantly effective（42.46%）,37 patients were effective（50.68%）,and 5 patients were ineffective（6.85%）.The total effective rate was 93.15%.In the control group,20 patients were significantly effective（27.40%）,35 patients were effective（47.94%）,and 18 patients were ineffective（24.66%）.The total effective rate was 75.43%.In the comparison of the data between the two groups,with statistical difference（χ^2=3.234,P=0.043）. Conclusion Application of nicorandil in the treatment of angina on the basis of regular treatment is not only able to improve curative effects,but also reduce incidence of adverse effects.It is also able to significantly improve patients′ life quality,alleviate patient′ s pain,and reduce the relapse rate,which is worthy of clinical promotion and application.