不同给药方式黄体酮治疗先兆流产临床效果研究

Clinical effect of different drug-delivery ways of progesterone in the treatment of threatened abortion

目的分析口服与肌内注射不同剂量黄体酮治疗先兆流产的临床效果。方法选取本院2012年2月2014年7月明确诊断为先兆流产患者124例为研究对象,将其随机分为四组,每组各31例。A组患者口服黄体酮胶囊,100 mg/次,2次/天;B组患者口服黄体酮胶囊,200 mg/次,2次/天;C组患者肌内注射黄体酮,20 mg/次,1次/天,至症状消失停药;D组患者肌内注射黄体酮,20 mg/次,2次/天,至症状消失后减量为20 mg/d,1周后停药。比较不同给药方式、不同剂量黄体酮对先兆流产的治疗效果。结果 A组患者保胎成功率为80.65%,B组为83.87%,C组为83.87%,D组为87.10%(χ2=0.48,P>0.05)。C、D组患者临床症状缓解时间短于A、B组(P<0.05)。四组患者妊娠结局比较无显著差异(P>0.05)。结论口服与肌内注射黄体酮具有相似的保胎率,但肌内注射能够在更短时间内缓解患者临床症状。

ObjectiveTo analyze the clinical effects of different doses of oral and intramuscular injection progesterone in the treatment of threatened abortion.MethodSelected from February 2012 to July 2014, 124 patients with threatened abortion in our hospital, randomly divided into 4 groups, 31 cases in each group, patients in group A were treated with progesterone capsules orally, 100 mg/time, 2 times/day, patients in group B were treated with progesterone capsules orally, 200 mg/time, 2 times/day, patients in group C were treated with progesterone intramuscular injection, 1 time/day, 20 mg/times, until the clinical symptoms disappeared, patients in group D were treated with intramuscular progesterone, 2 times/day, 20 mg/times, until the clinical symptoms disappeared the dose reduced to 20 mg/day, 1 week later withdrawal. Compared the clinical effect of different doses and different drug-delivery ways; progesterone in the treamented of threatened abortion. ResultFetus protection success rate of group A was 80.65%, group B was 83.87% group C was 83.87%, group D was 87.10% （χ2=0.48,P〉0.05）. Clinical symptom remission time of group C, D was shorter than group A, B （P〈0.05）, pregnancy outcomes of the 4 groups had no signiifcant differences （P〉0.05）. ConclusionOral and intramuscular injection progesterone have similar miscarriage rate, but intramuscular injection can alleviate clinical symptoms in a short time.