阿托伐他汀钙联合羟乙基淀粉注射液治疗分水岭脑梗死的临床效果研究

Clinical effect of atorvastatin calcium combined with hydroxyethyl starch in the treatment of cerebral watershed infarction

目的分析阿托伐他汀钙联合羟乙基淀粉注射液对分水岭脑梗死患者急性期和远期临床治疗效果。方法选取本院2013年2月至2014年6月收治的分水岭脑梗死患者78例为研究对象,采用随机数表法将其分为观察组和对照组,每组各39例,两组患者均给予稳压、降糖、抗血小板聚集等常规治疗,对照组患者在此基础上加用阿托伐他汀钙,观察组患者给予阿托伐他汀钙联合羟乙基淀粉注射液,比较两组患者急性期和远期的临床效果。结果治疗后7天,观察组患者日常生活能力和神经功能恢复均明显优于对照组(P<0.05);治疗后3个月,观察组患者神经功能及日常生活能力恢复均明显优于对照组,且治疗总有效率明显高于对照组(χ2=7.47,P<0.01)。结论阿托伐他汀钙联合羟乙基淀粉注射液在分水岭脑梗死患者急性期和远期均有较好的临床治疗效果。

ObjectiveTo analyze the clinical effect of atorvastatin calcium combined with hydroxyethyl starch in the treatment of cerebral watershed infarction in acute phase and forward.MethodSelected from February 2013 to June 2014, 78 cases patients with cerebral watershed infarction in our hospital, randomly divided into observation group and control group, 39 cases in each group, the two groups were treated with decreasing blood pressure, reducing blood glucosem, anti-platelet aggregation and other conventional drugs. Control group patients were treated with atorvastatin calcium, observation group patients were treated with atorvastatin calcium combined with hydroxyethy starch, the clinical effects of acute and long-term of the two groups were compared.ResultAfter 7 days treament, the activity of daily living and neurological recovery of observation group were signiifcantly better than control group （P〈0.05）; 3 months after treatment, total efifciency of observation group was signiifcantly higher than control group （χ2=7.47,P〈0.01）.Conclusion Atorvastatin calcium combined with hydroxyethyl starch in the treatment of cerebral watershed infarction has better clinical efficacy in acute phase and forward.