不同时间段给予替米沙坦治疗高血压的临床疗效及安全性分析

Different Time Periods Given Telmisartan Treatment of Hypertension Clinical Efficacy and Safety Analysis

目的:探究与分析不同时间段给予替米沙坦治疗高血压的临床疗效及安全性。方法:选取本院2012年12月-2014年12月收治的60例高血压患者,采取随机数字表法分为早间服药组与晚间服药组,每组各30例,早间服药组于每天早8∶00点服用替米沙坦,晚间服药组于每天晚20∶00点服用替米沙坦,对比两组患者的临床疗效。结果:早间服药组总有效率为90.00%,晚间服药组总有效率为93.33%,两组比较差异无统计学意义(字2=1.78,P>0.05)。早间服药组与晚间服药组白天收缩压与舒张压平均值比较,差异无统计学意义(P>0.05);但夜间比较差异有统计学意义(P<0.05);两组24 h收缩压与舒张压平均值比较,差异亦无统计学意义(P>0.05)。早间服药组恶心、头晕、头痛发生率分别为10.00%、16.67%、13.33%,晚间服药组恶心、头晕、头痛发生率分别为6.67%、13.33%、10.00%,两组比较差异无统计学意义(P>0.05)。结论:两种服用方法均可对高血压患者的血压产生影响,但晚间服药疗效明显优于早间服药,值得推广与应用。

Objective： To explore and analyze different time periods given telmisartan treatment of hypertension clinical efficacy and safety. Method： In our hospital from December 2012 to Deeember 2014 60 eases hypertensive patients were selected and divided into morning medication group and evening medication group, 30 eases in each group. Morning medication group took telmisartan at 8 ： 00 am, and evening medication group took telmisartan at 8 ： 00 pm. To compare curative effect between the two groups. Result： The total effective rate of the morning medication group was 90.00%, and that of the evening medication group was 93.33%, with no significant difference between the two groups （ x^2=1.78, P〉0.05 ） . Systolic and diastolic blood pressure between the two groups showed no significant difference during daytime and 24 h, but had at night. Nausea, dizziness, headache rate of the morning medication group was 10.00%, 16.67%, 13.33%, and that of the evening medication group was 6.67%, 13.33%, 10.00%, there was no significant difference between the two groups （P〉0.05） . Conclusion： Both methods can take effect on blood pressure in hypertensive patients, but clinical efficacy in the evening for hypertensive patients taking telmisartan was significantly better than the morning medication, worthy of promotion and application.