盐酸氨溴索注射液治疗慢性阻塞性肺疾病急性加重的临床效果观察

Clinical effect observation of ambroxol hydrochloride injection in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的 观察盐酸氨溴索治疗慢性阻塞性肺疾病急性加重（AECOPD）的临床效果。方法 选取2014年1~8月本院收治的AECOPD老年男性患者48例,将患者随机分成治疗组（25例）和对照组（23例）,两组均给予吸氧、抗生素、雾化吸入激素及支气管扩张剂等常规治疗,治疗组在常规治疗基础上加上盐酸氨溴索注射液60 mg。观察两组给药前后咳痰难易程度、痰的性状、痰量及肺部湿啰音的轻重程度。结果 治疗组的显效率、总体有效率分别为48.0%、88.0%,显著高于对照组的34.8%、73.9%（P〈0.05）。结论 对AECOPD患者而言,盐酸氨溴索注射液有助于其病情恢复,值得临床推广应用。

Objective To observe the clinical effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods From January to August 2014,48 elderly male patients with AECOPD treated in our hospital were selected and they were randomly divided into treatment group（25 cases） and control group（23 cases）.Conventional therapy of oxygen inhalation,antibiotics,aerosol inhalation of hormone,and bronchodilators were provided in both groups.Intreatment group,on the basis of the regular therapy,60 mg ambroxol hydrochloride injection was added.The degree of difficulty of expectoration,character of sputum,amount of sputum,and severity of pulmonary moist rale were observed before and after medication in two groups. Results The marked improvement rate and total effective rate in treatment group（48.0% and 88.0%） was obviously higher than that of control group（34.8% and 73.9%） respectively（P〈0.05）. Conclusion For patients with AECOPD,ambroxol hydrochloride injection is beneficial to disease recovery of patients,and it is worthy of promotion and application in clinic.