免疫性血小板减少症患者外周血淋巴细胞亚群变化的研究

Research the changes of peripheral blood lymphocyte subsets in patients with immune thrombocytopenia

目的 研究免疫性血小板减少症（ITP）患者外周血淋巴细胞亚群的变化,探讨其在疾病诊断、治疗与预后方面的作用。方法 以2012年1月~2014年1月鄂尔多斯市中心医院血液科收治的78例ITP患者作为ITP组,同时选择30例健康体检者作为对照组。检测两组外周血淋巴细胞亚群绝对值和血小板计数,采用SPSS 13.0统计学软件进行统计学分析。结果 ITP组与对照组比较,CD3＋T细胞、CD3＋CD4＋T细胞、CD4＋/CD8＋T细胞比值、CD16＋56＋NK细胞绝对值降低,CD3＋CD8＋T细胞、CD19＋B细胞绝对值升高,差异有统计学意义（P〈0.05）;ITP组治疗后淋巴细胞亚群的变化早于血小板的变化。结论 淋巴细胞亚群检测对ITP的辅助诊断及治疗效果的评估有较好的应用价值。

Objective To study the changes of peripheral blood lymphocyte subsets in patients with immune thrombocytopenia and to discuss the role in the diagnosis,treatments and prognostic. Methods 78 patients with immune thrombocytopenia reduction who were treated in the department of hematology of erdos central hospital from January 2012 to January 2014 were selected as ITP group.At the same time,30 healthy subjects were chosen as control group.The absolute value of peripheral blood lymphocyte subsets and the platelet counts between two groups was detected respectively.The statistical analysis was performed by SPSS 13.0 statistical software. Results Compared with ITP group and the control group,the number of CD3＋T cells,CD3＋CD4＋T cells,CD4＋/CD8＋T cells and CD16＋56＋NK cells was decreased respectively,while the number of CD3＋CD8＋T cells and CD19＋B cells was increased respectively,with statistical difference（P〈0.05）.The changes in ITP group after treatment was earlier in lymphocyte subsets than platelet. Conclusion The detection of lymphocyte subsets has good application values for diagnosis and evaluation of the effect on the treatment to immune thrombocytopenia.