大连地区儿童过敏原检测结果分析

The analysis of serum specific allergen test results among children with allergic diseases in Dalian district

目的 分析大连地区过敏性疾病患儿血清总IgE和血清特异性IgE（sIgE）抗体水平及不同年龄组sIgE抗体的构成情况。方法 应用速率散射比浊法检测2013年12月~2014年12月在本院就诊的185例过敏性疾病患儿血清总IgE抗体,用免疫印迹法检测sIgE抗体。结果 总IgE抗体阳性率为54.1%,sIgE抗体阳性率为43.8%,其中吸入性过敏原阳性率为41.1%,以尘螨最为常见,占阳性患者的71.1%。食入性过敏原阳性率为31.6%,以鸡蛋白最为常见,占阳性患者的30.5%。不同年龄组患儿吸入性过敏原阳性率差异有统计学意义（P=0.028）,不同年龄组患儿食入性过敏原、总IgE抗体阳性率差异无统计学意义（P=0.522;P=0.479）。不同年龄组单一过敏原和多重过敏原比例比较,差异有统计学意义（χ2=8.752,P〈0.05）。结论 本地区不同年龄组过敏性疾病患儿的血清过敏原构成不同,故应针对不同年龄组的患儿采取不同的预防措施。

Objective To analyze serum total IgE and allergen specific IgE（slg E） antibody level in children with allergic disease of Dalian district and analyze constitution of slg E antibody in different age groups. Methods Serum total IgE antibody was detected by speed scattering turbidimetric method,slg E antibody was detected by Western blotting in185 children with allergic disease treated in our hospital from December 2013 to December 2014. Results The positive rate of total IgE antibody was 54.1%.The positive rate of slg E antibody was 43.8%,among them,positive rate of inhaled allergen was 41.1%,the dust mite was the most common,and it accounted for 71.1% of the positive patients.The positive rate of food allergen was 31.6%,chicken protein was the most common,and it accounted for 30.5% of the positive patients.There was a statistical difference of positive rate of inhaled allergen in different age groups（P=0.028）.there was no statistical difference of the positive rate of food allergen and total IgE antibody in different age groups（P=0.522;P=0.479）.there was a statistical difference of proportion of single allergen and multiple allergen in different age groups（χ2=8.752,P〈0.05）. Conclusion The serum allergen constitution of children with allergic disease in different age groups of this area is different,so the children of different age groups should be given different preventive measures.