血浆D-二聚体测定在食管癌诊治中的价值

The Value of D-Dimer in the Diagnosis and Treatment of Esophageal Cancer

目的：探讨血浆D-二聚体水平在食管癌患者诊治中的临床价值。方法：测定120例食管癌患者血浆D-二聚体水平，并与健康对照组进行比较，分析食管癌患者术前D-二聚体水平与临床病理特征的关系及手术前后D-二聚体水平变化。结果：食管癌组术前血浆D-二聚体水平显著高于健康对照组，并随TNM分期的进展而升高，有并发症者术前D二聚体水平显著高于无并发症组，术后2周D-二聚体水平显著低于术前，Ⅲ～Ⅳ期患者下降更为显著，有并发症组术后2周D-二聚体水平仍显著高于健康对照组（P〈0.05）。结论：D-二聚体检测方法灵敏度高，可作为食管癌患者辅助诊断、治疗及手术风险评价的指标。

Objective： To explore the value of D-Dimer level in the diagnosis and treatment for patients with esophageal carcinoma. Method： The level of D-Dimer of 120 eases of patients with esophageal carcinoma was tested before and after operation, and was compared with healthy eobert.Exploring the relationship between the level of D-Dimer and the clinical and patholagieal parameters, analyzing the variation of D-Direct before and after esophagectomy.Result： The D-Dimer level of patients with esophageal cancer was higher than that of the healthy cohort.Compared with early stage, the level of D-Dimer was higher in patients with advanced TNM stage cancer.Groups were comparable in clinical features.The increase of preoperative D-Dimer was related to postoperative combination.The D-Dimer of the most patients decreased dramatically 2 weeks after the treatment of surgery, especially in the Ⅲ-Ⅳ TNM stage cases, however the level of the patients with serious postoperative combinations was still higher than the healthy eohort（P〈0.05）.Conclusion： D-Dimer is a reliable sensitive factor and is helpful for the auxiliary diagnosis and treatment.It is also a predictor of the surgical risk for the esophageal carcinoma.