溶血栓药物的发展概况

An overview of development of thrombolytic drugs

近年来,对溶血栓药物的研究取得了较大进展。本文对包括尿激酶(urokinase,UK)、链激酶(streptokinase,SK)、组织型纤溶酶原激活剂(tissue type plasminogen activator,t PA)、葡激酶(straphylokinase,Sa K)、纳豆激酶(nattokinase,NK)、重组型纤溶酶原激活物在内的历代溶血栓药物的发展历程、基本性质、优缺点、溶血栓机制及发展方向作一综述。

In recent years, the research on thrombolytic drugs has made a great progress. This article describes the development process, basic properties, advantages and disadvantages, thrombolytic mechanisms and prospects of successive thrombolytic drugs, including urokinase（UK）, streptokinase（SK）, tissue type plasminogen activator（t PA）, straphylokinase（Sa K）, nattokinase（NK）and recombinant plasminogen activator.