生长抑素联合洛赛克治疗难治性上消化道出血

Clinical treatment observation of patients with refractory upper gastrointestinal bleeding

目的 探讨难治性上消化道出血临床治疗方法.方法 选取2013年5月至2014年5月收治的难治性上消化道出血患者100例,随机分为对照组和观察组,每组50例.对照组单用生长抑素治疗,观察组联用洛赛克治疗,对两组疗效进行比较.结果 观察组止血有效率为86％,明显高于对照组的52％,差异有统计学意义（P＜0.05）.观察组止血时间明显短于对照组,差异有统计学意义（P＜0.05）.观察组再出血率为8％,明显低于对照组的22％,差异有统计学意义（P＜0.05）.结论 难治性上消化道出血采用生长抑素联合洛赛克治疗,可显著提高止血有效率,缩短止血时间,降低降出血率,对保障患者生命健康及生存质量意义重大,值得临床推广应用.

Objective To investigate the clinical treatment method of refractory upper gastrointestinal bleeding.Methods From May 2013 to May 2014,100 cases of refractory upper gastrointestinal bleeding were chose,and randomly divided into two groups,with 50 cases in each group.Patients in control group were given simple application of somatostatin therapy,and patients in observation group were given somatostatin combined with omeprazole treatment.The effects of the two groups were compared.Results The hemostasis effective rate in observation group was 86%,which was significantly higher than that in control group（52%）,the difference was significant （P 〈 0.05）.Bleeding time was significantly shorter in observation group than that in control group,there was significant difference（P 〈0.05）.The rebleeding rate was 8% in observation group,which was significantly lower than that in control group （22%）,there was significant difference （P 〈 0.05）.Conclusions Somatostatin combined with omeprazole in treatment of refractory upper gastrointestinal bleeding can significantly improve the efficiency of hemostasis,shorten the bleeding time and reduce bleeding rates,has important significane in protecting life and health and quality of life,and is worthy of extensive clinical application.