脓毒症休克患者凝血功能及血浆蛋白C水平与预后的相关性研究

Correlation of blood coagulation function and plasma protein C level with prognosis of patients with septic shock

目的:探讨脓毒症休克患者凝血功能及血浆蛋白C水平与预后的相关性研究。方法:收集我院近3年共83例诊断为脓毒症的患者作为研究对象,按患者预后分为病例组(脓毒症休克存活患者)和对照组(脓毒症休克死亡患者)。比较对照组和病例组凝血指标及血浆蛋白C。结果:对照组凝血酶原时间、凝血酶时间、活化部分凝血酶时间、D-二聚体、纤维蛋白原及血浆蛋白C明显高于病例组(P<0.05)。结论:本次研究认为凝血指标中凝血酶原时间、D-二聚体与脓毒症休克病情严重程度及预后有一定相关,及早干预并治疗凝血功能紊乱,对于提高患者的存活率有积极的意义。

Objective To investigate the correlation of blood coagulation function and plasma protein level with prognosis. Methods： 83 patients with sepsis were divided into survival group and death group,and the coagulation index and plasma protein C of the two groups were compared. Results The prothrombin time,thrombin time, activated partial thromboplastin time, D- dimer, fibrinogen and plasma protein C were significantly higher death in group in than survival group （P〈0.05）. Conclusion This study suggests that there is a certain correlation of prothrombin time and D- dimer with the severity and prognosis of septic sheck, early intervention and treatment of coagulation disorders may improve the survival rate of patients.