酪氨酸蛋白激酶7在胃腺癌中的表达及临床意义

Clinical significance of expression of protein tyrosine kinase 7 in gastric adenocarcinoma

目的:研究酪氨酸蛋白激酶7(protein tyrosine kinase 7,PTK7)在胃腺癌(gastric adenocarcinoma,GAC)中的表达及临床意义.方法:收集210例接受D2/D3胃癌根治术GAC患者的手术切除标本以及30例正常癌旁胃黏膜组织,免疫组织化学Envision法检测PTK7在GAC组织及正常组织中表达差异,分析PTK7在GAC中的表达差异与患者临床病理资料以及3年生存率之间的关系.结果:PTK7在GAC中的阳性表达明显比正常组织中高(87.14%vs 22.86%,P<0.05).在GAC中,PTK7的表达与患者的性别,年龄,肿瘤位置及大小无关(P>0.05),与肿瘤的Lauren分型(P=0.011),分化程度(P=0.039),浸润深度(P=0.025)和是否转移(P=0.034)相关,PTK7阴性表达患者3年生存率更高(39.89%vs 62.96%,P<0.05).结论:(1)PTK7在GAC组织中的表达水平显著高于其正常的胃黏膜组织;(2)PTK的高表达与GAC的临床病理特征密切相关;(3)PTK7可能成为评价GAC患者预后的指标;(4)PTK7可能成为潜在的GAC早期诊断分子标志物或治疗靶点.

AIM： To explore the role of protein tyrosine kinase 7 （PTK7） in gastric adenocarcinoma （GAC）. METHODS： A total of 210 ℃ tissue samples and 30 normal gastric mucosal tissues were obtained from patients who underwent D2/ D3 lymphadenectomy. Immunohistochemical method was used to detect the expressionof PTK7 in GAC tissues and normal gastric mucosa tissues. The correlations of expression of PTK7 in GAC with clinical characteristics and 3-year survival rate in GAC patients were analyzed. RESULTS： In GAC tissues and normal gastric mucosa tissues, the expression of PIK7 differed significantly （87.14% vs 22.86%, P 〈 0.05）. In GAC tissues, the expression of PTK7 has no significant correlation with gender, age, tumor location or size （P 〉 0.05）, but was significantly correlated with Lauren classification （P -- 0.011）, differentiation （P = 0.039）, invasion depth （P=0.025） and distant metastasis （P = 0.034）, In GAC patients, positive expression of PTK7 was associated with a poorer 3-year survival rate compared with patients with negative expression of PTK7 （39.89% vs 62.96%, P 〈 0.05）. CONCLUSION： The expression of PTK7 in GAC is higher than that in normal gastric mucosa tissues, and high expression of PTK7 is related to clinical pathological characteristics. PTK7 may be a useful biomarker to predict the prognosis for patients with GAC. PTK7 might be a potential therapeutic target for GAC.