270例精神分裂症患者肝胆彩色多普勒超声结果分析

Analyses of the hepatobiliary color Doppler ultrasound in patients with schizophrenia

目的：探讨服用抗精神病药物的精神分裂症患者肝胆彩色多普勒超声异常改变情况及影响因素。方法：随机选取2009年3月至2014年11月在我院就诊的门诊及住院精神分裂症患者共270例,服用抗精神病药的精神分裂症患者202例构成研究组,未服用抗精神病药的首发精神分裂症患者68例为对照组。比较两组研究对象肝胆彩色多普勒超声检查阳性率差异,以及药物种类、用药方法、用药时间、年龄及性别对肝胆彩色多普勒超声检查阳性率的影响。结果：研究组肝胆彩色多普勒超声检查阳性率（44.1%）显著高于对照组（26.5%）,差异有统计学意义（P〈0.05）。在研究组中,单一典型抗精神病用药、联合用药、用药时间10年以上及60岁以上患者肝胆彩色多普勒超声检查阳性率分别显著高于单一非典型抗精神病用药、单一用药、用药时间3～10年及60岁以下患者,差异有统计学意义（P〈0.05）,但男性与女性的肝胆彩色多普勒超声检查阳性率比较,差异无统计学意义（P〉0.05）。结论：典型抗精神病药、联合用药、用药时间10年以上及60岁以上患者加重抗精神病药物对肝胆功能的损害,建议定期进行肝胆彩色多普勒超声检查以及肝功能检查,以便早期发现、早期治疗。

Objective： To explore the abnormal changes factors of hepatobiliary color Doppler ultrasound in schizophrenic patients treated with antipsychotics. Methods： 202 cases of schizophrenia patients treated with antipsychotic drugs were chosen as study group. 68 cases of schizophrenic patients not taking antipsychotics were chosen as control group. Compared the positive rate of hepatobiliary color Doppler ultrasound between the two groups,as well as types of drug,treatment methods,medication time,age and gender impacted on hepatobiliary color Doppler sonography positive rate. Results： The positive rate of hepatobiliary color Doppler ultrasound in the study group（ 44. 1%） was higher than that in the control group（ 26. 5%）（ P〈0. 05）. The positive rates of of hepatobiliary color Doppler ultrasound in schizophrenic patients with single typical antipsychotic medication,combined medication,medication time more than 10 years and aged over 60 were respectively significantly higher than those in schizophrenic patients with single atypical antipsychotic medication,a single medication,medication3-10 years and under the age of 60（ P〈0. 05）,but there was no differences in gender（ P〉0. 05）. Conclusion：The factors of typical antipsychotics,combined medication,medication for more than 10 years and aged over 60 increase the hepatobiliary function impairment of the antipsychotic drugs, these people should be regularly examined by hepatobiliary color Doppler ultrasound for early detection and early treatment.