维持性血液透析患者桡动脉钙化及其危险因素分析

Radial Artery Calcification and Risk Factors in Maintenance Hemodialysis Patients

目的:探讨维持性血液透析(MHD)患者桡动脉钙化(RAC)及其危险因素。方法:收集MHD患者行自体动静脉内瘘(AVF)成形术废弃的桡动脉,行钙化染色后观察,记录一般情况和检测生化指标,多因素Logistic回归分析RAC的危险因素。结果:116例MHD患者中21例(18.1%)存在不同程度的RAC。钙化组男性比率、糖尿病发病率、透析时间、全段甲状旁腺激素(i PTH)水平较非钙化组差异有统计学意义(P<0.05),多因素Logistic回归分析结果显示,糖尿病、中位透析龄≥60个月与RAC的发生呈正相关。结论:糖尿病、中位透析龄≥60个月是MHD患者RAC的重要危险因素,男性、i PTH升高与RAC密切相关。

Objective： To investigate the status of radial artery calcification （RAC） in maintenance hemodialysis （MHD） pa- tients, and explore risk factors. Methods：Segment of radial artery were obtained from the operation of arteriovenous fistula（AVF） in MHD patients. RAC were observed by yon kossa staining. The clinical and biochemical data were collected. The parameters relating to RAC were then analyzed by binary Logistic regression analysis. Results：Among 116 cases of MHD patients ,21 cases（ 18.1% ）were developed RAC in different degrees. Male, diabetics, duration of dialysis, intact parathyroid hormone（iPTH） were statistical differ- ences between two groups （P 〈0.05）. Binary Logistic regression analysis showed that diabetics and duration of dialysis1〉60 months were positively correlated with RAC. Conclusion ： Diabetics and duration of dialysis ≥60 months were main influential factors of RAC in MHD. Male and iPTH were closely correlated with RAC.