吲达帕胺联合厄贝沙坦治疗高血压合并早期肾损害的临床疗效观察

Therapeutic Effect of Indapamide Combined with Irbesartan on Hypertension with Early Renal Damage

目的:研究吲哒帕胺联合厄贝沙坦对高血压合并早期肾功能损害的临床治疗效果。方法:选择于我院就诊的高血压合并早期肾损害患者124例,随机分为两组,各62例。对照组单用吲达帕胺,治疗组吲达帕胺联合使用厄贝沙坦。分别于治疗前,治疗后4周,治疗后8周监测患者血压、24h尿蛋白定量、血尿酸、血肌酐、血钾。对比两组之间的差异。结果:治疗后4周治疗组舒张压、收缩压均低于对照组,治疗组血钾高于对照组,两组之间24 h尿蛋白定量、血尿酸、血肌酐对比无统计学差异。治疗后8周治疗组舒张压、收缩压均低于对照组,治疗组血钾高于对照组,治疗组24 h尿蛋白定量、血尿酸均低于对照组,两组之间血肌酐对比无统计学差异。结论:厄贝沙坦和吲达帕胺联合治疗高血压合并早期肾功能损害效应互补,效果良好,副作用小,是一种较好的联合降压方案。

Objective： To study the therapeutic effect of Indapamide combined with Irbesartan on hypertension with early renal damage. Methods：124 hypertension patientes with early renal damage in our hospital were divided into 2 groups randomly. The control group were treated with Indapamide alone while the treatment group were treated with Indapamide combined with Irbesartan.The blood pressure, 24-hour urine protein, blood uric acid, serum creatinine and potassium were compared before therapeutics , 4 weeks after therapeutics and 8 weeks after therapeutics respectively. Results： Four weeks after therapeutics, diastolic and systolic pressure of the treatment group were lower than that of control group while the potassium was higher than that of control group. There was no statistical significance of the difference of 24-hour urine protein, blood uric acid and serum creatinine between the two groups. Eight weeks after therapeutics ,diastolic pressure ,systolic pressure, 24-hour urine protein and blood uric acid of the treatment group were lower than that of control group while the potassium was higher than that of control group. There was also no statistical significant difference in serum creatinine between the two groups. Conclusion：Indapamide combined with Irbesartan is a good treatment protocols on hypertension with early renal damage.