急性呼吸窘迫综合征患者血清氨基末端B型脑钠肽前体水平的意义被引量：4

The Significance of Serum N-terminal Pro-brain Natriuretic Peptid Concentration in Patients with ARDS

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摘要目的:探讨急性呼吸窘迫综合征(ARDS)患者血清氨基末端B型脑钠肽前体水平(NT-pro BNP)的意义。方法:采用前瞻性研究方法,选取ARDS患者,测定血清NT-pro BNP;衡量其与病情严重程度的相关性;比较不同3日NT-pro BNP增长百分比组APACHEⅡ评分、机械通气时间、ICU住院天数、死亡率的差异。结果:ARDS组血清NT-pro BNP水平较对照组明显升高;不同严重程度的ARDS患者中,入院及3日NT-pro BNP水平有明显差异,且NT-pro BNP水平与Murray急性肺损伤评分有良好相关性;NT-pro BNP增长百分比(ΔNTpro BNP3)≥30%组APACHEⅡ评分、机械通气时间、ICU住院天数、死亡率均高于ΔNT-pro BNP3<30%组。结论 :血清NT-pro BNP水平在ARDS的诊断、病情严重程度分级及预后判断中有一定临床价值。 Objective：To investigate the significance of serum N-terminal pro-brain natriuretic peptid concentration in patients with ARDS. Methods：A prospective research was performed to compare the difference of NT-proBNP level between ARDS group and control group; We measure the correlation of NT-proBNP level and the severity of ARDS; APACHEII score,time of mechanical ventilation, days of hospitalization in ICU and mortality were compared among different groups. Results：The level of serum NT-proBNP in ARDS group was higher than that of control group; There are obvious difference on NT-proBNP level among patients with different severity. NT-proBNP levels in ARDS group are positively correlated with Murray acute lung injury score. Compared to group of ΔNT-proBNP3 〈30% , group of ΔNT-proBNP3≥30% have higher APACHEII score,time of mechanical ventilation, days of hospitalization in ICU and mortality. Conclusion：N-terminal pro-brain natriuretic peptid become a more effective means of diagnosis, severity level and prognosis in patients with ARDS.

作者张月辉林锦乐张文武田方王伟苏盛元王立军

机构地区南方医科大学附属深圳宝安医院重症医学科南方医科大学附属深圳宝安医院急诊科

出处《岭南急诊医学杂志》 2015年第4期286-289,共4页 Lingnan Journal of Emergency Medicine

基金宝安区科技计划社会公益项目(立项编号:2013017)

关键词急性呼吸窘迫综合征氨基末端B型脑钠肽前体 N-terminal pro-brain natriuretic peptid acute respiratory distress syndrome

分类号 R563.8 [医药卫生—呼吸系统]

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