胃舒宁联合奥美拉唑、克拉霉素、左氧氟沙星抗Hp治疗临床疗效观察

Observation of clinical effect by Weishuning combined with omeprazole, clarithromycin and levofloxacin in anti-Hp treatment

目的探讨胃舒宁联合奥美拉唑、克拉霉素、左氧氟沙星抗幽门螺杆菌(Hp)治疗的临床疗效。方法 793例Hp患者随机分成治疗组270例(胃舒宁联合奥美拉唑、克拉霉素、左氧氟沙星)、三联组264例(奥美拉唑、克拉霉素、左氧氟沙星)、对照组259例(奥美拉唑、甲硝唑、阿莫西林)。对三组治疗后的临床疗效进行分析。结果治疗组痊愈率87.0%,有效率4.1%,总有效率91.1%,无效率8.9%,消化道副作用11.9%,且症状轻。三联组痊愈率81.4%,有效率3.0%,总有效率84.5%,无效率15.5%,消化道副作用23.1%。对照组痊愈率64.5%,有效率9.3%,总有效率73.7%,无效率26.3%,消化道副作用43.2%。治疗组与三联组的疗效相当,但消化道副作用明显减轻(P<0.05),治疗组与对照组相比具有明显疗效(P<0.05)。结论中西医结合有良好的抗Hp治疗作用且消化道副作用小的优势,值得研究。

Objective To investigate clinical effect by Weishuning combined with omeprazole, clarithromycin and levofloxacin in anti-helicobacter pylori （Hp） treatment.Methods A total of 793 Hp patients were randomly divided into treatment group with 270 cases （Weishuning combined with omeprazole, clarithromycin and levofloxacin）, triple group with 264 cases （omeprazole, clarithromycin and levofloxacin） and control group with 259 cases （omeprazole, metronidazole and amoxicillin）. Clinical effects of the three groups were analyzed after treatment.Results The treatment group had cure rate as 87.0%, effective rate as 4.1%, total effective rate as 91.1%, ineffective rate as 8.9%, and gastrointestinal adverse reactions as 11.9% with slight symptoms. The triple group had cure rate as 81.4%, effective rate as 3.0%, total effective rate as 84.5%, ineffective rate as 15.5%, and gastrointestinal adverse reactions as 23.1%. The control group had cure rate as 64.5%, effective rate as 9.3%, total effective rate as 73.7%, ineffective rate as 26.3%, and gastrointestinal adverse reactions as 43.2%. The treatment group had similar curative effect with the triple group, while its gastrointestinal adverse reactions were much slighter （P〈0.05）. Compared with the control group, the treatment group had remarkably curative effect （P〈0.05）. Conclusion Integrated Chinese and Western medicines have advantages of good effect in anti-Hp treatment and few gastrointestinal side reactions, and it is worthy of research.