一种3-甲基黄嘌呤纯化工艺研究

A purification method of 3-methylxanthine

考察了HZl6c型大孔吸附树脂对3-甲基黄嘌呤粗粉的纯化工艺。利用吸附及解吸的单因素影响试验，筛选树脂的最佳工艺条件。最佳纯化工艺条件为：HZl6c型大孔吸附树脂静态吸附量为22．5mg／g；上样液3-甲基黄嘌呤pH为9．5～10．0；解吸溶剂为60％乙醇溶液（pH10．0），控制解吸速度为2．0mL／min，解吸体积约为3倍树脂体积（3BV）。该3-甲基黄嘌呤的纯化工艺路线收率达到75％。大孔吸附树脂HZl6c能有效纯化3-甲基黄嘌呤，该工艺简捷，有一定工业化应用价值。

The purification process of 3-methylxanthine by HZ16c nmcroporous resin is studied. The optimal purification conditions of resin are obtained based on adsorption and desorption. The key optimum conditions are ： about 22.5 mg/g of the static adsorption capacities of HZ16e resin for 3-methylxanthine, 60% alcohol （ pH 10.0 ） as the elution ,2. 0 mL/min of eluting velocity and about 3 BV of elution volume. The average yield of purification process of 3- methylxanthine reaches 75%. HZ16c resin is an ideal macroporous adsorbent for separating and purifying 3- methylxanthine. This purification process could be used in industrial production.