2009～2014年西安地区体检人群中肝炎病毒血清学检测回顾性分析

Retrospective Analysis on Serological Detection of Hepatitis Viruses in Physical Examination Population in Xi’an During 2009~2014

目的：回顾性分析陕西省西安地区体检人群中各型肝炎病毒血清学流行情况。方法利用酶联免疫吸附试验（ELISA）检测2009～2014年陕西省西安地区体检者血清中甲型肝炎病毒（HAV）抗体 IgM，乙型肝炎病毒表面抗原（HB-sAg），丙型肝炎病毒（HCV）抗体 IgG，丁型肝炎病毒（HDV）抗体 IgM，戊型肝炎病毒（HEV）抗体 IgM 和 IgG。结果1315例体检者血清中 HAV IgM 阳性率为0.15％（2／1315）；109965例体检者血清中 HBsAg 阳性率为2.83％（3360／109965），HBsAg 阳性率总体呈下降趋势（χ2＝63.070，P ＝0.001）；各年度之间男性体检者血清中 HBsAg 阳性率无显著性差异（χ2＝4.804，P ＝0.441），而各年度之间女性体检者血清中 HBsAg 总体阳性率逐年下降（χ2＝18.046，P ＝0.003），男性体检者血清中 HBsAg 阳性率明显高于女性（χ2＝126.9，P ＝0.000）；41898例体检者血清中 HCV 抗体阳性率为0.79％（333／41898），HCV 抗体阳性率逐年下降（χ2＝18.380，P ＝0.003）；1079例体检者血清中未检测出丁型肝炎病毒抗体IgM；1195例体检者血清中 HEV IgM 阳性率为0.25％（3／1195），而 HEV IgG 阳性率为3.93％（47／1195）。结论2009～2014年体检者中肝炎病毒感染以 HBV 和 HCV 为主，而且呈总体下降趋势，为陕西省西安地区各型肝炎病毒血清学流行情况提供了资料和防控依据。

Objective To investigate retrospective analysis on serological detection of hepatitis viruses in physical examination population.Methods Hepatitis A virus （HAV）IgM,HBsAg,HCV IgG,HDV IgM,HEV IgM and HEV IgG were detected by ELISA assay in physical examination population during 2009~2014.Results The positive rate of HAV IgM was 0.15%（2/1 315）in 1 315 physical examinees and that of HBsAg was 2.83% （3 360/109 965）in 109 965 ones during 2009~2014. The positive rates of HBsAg decreased trend in the last 6 years in general （χ2 =63.070,P =0.001）.There was no signifi-cant difference for HBsAg positive rate among male physical examinees in last six years （χ2 =4.804,P =0.441）,but the positive rate of HBsAg in female population decreased trend in the last 6 years in general （χ2 =18.046,P =0.003）,moreo-ver the positive rate of HBsAg in male popolation was significantly higher than that in female ones （χ2 =126.9,P =0.000）. The positive rate of HCV IgG was 0.79% （333/41 898）in 41 898 physical examinees during 2009~2014 and that decreased trend in last 6 years （χ2 = 18.380,P =0.003）.There was no HDV IgM detected in 1 079 physical examinees serum.The positive rate of HEV IgM and IgG were 0.25% （3/1 195）and 3.93% （47/1 195）respectively in 1 195 physical examinees. Conculsion The physical examination population during 2009~2014 were mainly infected by HBV and HCV and the infec-tion rate decreased trendly in last 6 years,which provided important data for epidemiology of serological hepatitis viruses in Shaanxi provice.