肺结核并发糖尿病患者外周血白细胞介素-22含量检测

Expression and Clinical Significance of Serum IL-22 on Patients with Pulmonary Tuberculosis and Diabetes Mellitus

目的：检测肺结核并发糖尿病（PPTDM）患者外周血血清 IL-22含量并分析其意义。方法 ELISA 检测30例PPTDM 患者、30例肺结核（PTB）患者、30例糖尿病（DM）患者和30例健康志愿者（HV）血清 IL-22含量并分析其意义。结果PPTDM 组血清 IL-22含量（54.4±4.81 pg／ml）显著低于 DM 组（72.36±5.12 pg／ml）和 HV 组（68.32±3.08 pg／ml），差异均有统计学意义（t＝2.557，P ＝0.013；t ＝2.437，P ＝0.018）。PPTDM 组血清 IL-22含量高于 PTB 组（45.36±5.88 pg／ml），但差异无统计学意义（t＝1.190，P ＝0.239）。不同形式肺结核并发糖尿病患者血清 IL-22含量检测结果中，先患肺结核后患糖尿病（PTB-DM）组血清 IL-22含量（64.62±8.59 pg／ml）显著高于先患糖尿病后患肺结核（DM-PTB）组（44.21±2.68 pg／ml），差异有统计学意义（t ＝2.267，P ＝0.031）。结论IL-22在 PPTDM 疾病发生中可能具有重要作用。

Objective To study serum IL-22 levels in patients with pulmonary tuberculosis and diabetes mellitus （PPTDM） and to analysis their clinical significance.Methods ELISA was used to detect serum IL-22 levels in 30 cases PPTDM pa-tients,30 cases pulmonary tuberculosis （PTB）patients,30 cases diabetes mellitus （DM）patients and 30 cases healthy vol-unteers （HV）.Results Serum IL-22 levels of PPTDM patients （54.4±4.81 pg/ml）were significantly lower than those in diabetes mellitus （DM）patients （72.36±5.12 pg/ml）and healthy volunteers （HV）（68.32±3.08 pg/ml）（t=2.557,P =0.013;t=2.437,P =0.018）,respectively.There was no significantly different of serum IL-22 levels between PPTDM and PTB patients （t=1.190,P =0.239）.Serum IL-22 levels of diabetes mellitus coincident with pulmonary tuberculosis （DM-PTB）patients （64.62±8.59 pg/ml）were significantly higher than those in pulmonary tuberculosis coincident with diabetes mellitus （PTB-DM）patients （44.21±2.68 pg/ml）（t=2.267,P =0.031）.Conclusion IL-22 may play an important role in PPTDM development.