期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Wnt信号通路及其调节因子与骨质疏松的关系

Wnt signaling pathway and its regulatory factors in osteoporosis
原文传递
导出
摘要 在骨发育过程中Wnt信号通路发挥着非常重要的作用,而DKK1是Wnt信号通路的重要抑制因子。本文就Wnt信号通路、DKK1及其拮抗剂在骨代谢中的作用及其对骨质疏松发生发展的影响等相关研究进展进行综述,为骨质疏松症的有效治疗提供理论依据。 Wnt signaling pathway plays an important.role in the process of bone growth. Nevertheless, DKK1 is a vital inhibitor in Wnt signaling pathway. In this review, we summarized recent correlative studies about the effect of Wnt signaling pathway and DKK 1 together with its antagonists on bone metabolism and osteoporosis to provide theoretical basis for effective treatment on osteoporosis.
作者 赵宇 毛立群 郭小芹 李玲 王越 韩泽民
机构地区 武警后勤学院附属医院口腔科 武警后勤学院病原生物和免疫学教研室 武警后勤学院药理学教研室
出处 《武警后勤学院学报（医学版）》 CAS 2015年第7期584-588,共5页 Journal of Logistics University of PAP（Medical Sciences）
基金 国家自然科学基金项目(81273520) 天津市自然科学基金重点项目(12JCZDJC26300) 武警后勤学院科学技术研究项目(WHB201404 WHB201405 WHB201406)
关键词 WNT DKK-1 骨质疏松 Wnt DKK-1 Osteoporosis
分类号 R589.5 [医药卫生—内分泌]
  • 相关文献

参考文献36

  • 1Wilusz M, Majka M. Role of the Wnt//~-catenin network in regulating hematopoiesis[J]. Arch Immunol Ther Exp (Warsz), 2008, 56(4):257-266.
  • 2Logan CY, Nusse R. The Wnt signaling pathway in development and disease[J]. Annu Rev Cell Dev Biol, 2004, 20: 781-810.
  • 3Silv~rio KG, Davidson KC, James RG, et al. Wnt//3-catenin pathway regulates bone morphogenetic protein (BMP2)-me- diated differentiation of dental follicle cells[J]. J Periodontal Res, 2012, 47(3):309-319.
  • 4Issack PS, Helfet DL, Lane JM. Role of Wnt signaling in bone remodeling and repair[J]. HSS Journal, 2008, 4(1):66-70.
  • 5Qiang YW, Shaughnessy Jr JD, Yaccoby S. Wnt3a signaling within bone inhibits multiple myeloma bone disease and tu- mor growth[J]. Blood, 2008, 112(2):374-382.
  • 6岳二丽,杨晓喻,赵红宇.Wnt信号通道组成及其在成骨细胞分化增殖中的效应[J].中国口腔种植学杂志,2008,13(4):195-199. 被引量：5
  • 7O'Shea PJ, Kim DW, Logan JG, et M. Advanced bone formation in mice with a dominant-negative mutation in the thyroid hor- mone receptor/3 gene due to activation of Wnt/13-catenin pro- tein signaling[J]. J Biol Chem, 2012, 287:17812-17822.
  • 8Watanabe K. Osteoblast differentiation and bone formation. [J]. Nihon Rinsho, 2009, 67(5):879-886.
  • 9Si W. CCNI/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells[J]. Mol Cell Biol, 2006, 26(8):2955-2964.
  • 10Minear S, Leucht P, Jiang J, et al. Wnt proteins promote bone regeneration[J]. Sci Transl Med, 2010, 2(29):29-30.

二级参考文献63

  • 1赖巧红,章汉旺.Dickkopf-1 mRNA在妊娠小鼠围着床期子宫内膜的表达[J].生殖医学杂志,2006,15(3):184-187. 被引量：2
  • 2Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway[ J ]. J Cell Sci ,2003,116:2627-2634.
  • 3Pinzone JJ,Hall BM,Thudi NK,et al. The role of Dickkopf-1 in bone development, homeostasis, and disease [ J ]. Blood ,2009,113:517-525.
  • 4Katoh M, Katoh M. WNT signaling pathway and stem cell signaling network [ J ]. Clin Cancer Res, 2007,13 : 4042- 4045.
  • 5Tulac S, Overgaard MT, Hamilton AE, et al. Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells[ J ]. J Clin Endocrinol Metab ,2006,91 : 1453-1461.
  • 6Hayashi K, Burghardt RC, Bazer FW, et al. WNTs in the ovine uterus:potential regulation of periimplantation ovine conceptus development [ J ]. Endocrinology, 2007, 148: 3496-3506.
  • 7Stephenson M, Kutteh W. Evaluation and management of recurrent early pregnancy loss [ J ]. Clin Obstet Gynecol, 2007,50 : 132 - 145.
  • 8Brown S. Miscarriage and its associations [ J ]. Semin Reprod Med,2008 ,26 :391-400.
  • 9Schumacher A, Brachwitz N, Sohr S, et al. Human chorionic gonadotropin attracts regulatory T cells into the fetalmaternal interface during early human pregnancy [ J ]. J Immunol,2009 ,182 :5488-5497.
  • 10Kammerer U, Kruse A, Barrientos G, et al. Role of dendritic cells in the regulation of maternal immune responses to the fetus during mammalian gestation[ J]. Immunol Invest, 2008,37 : 499 -533.

共引文献15

武警后勤学院学报（医学版）
2015年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部