连续性血液净化对急性呼吸窘迫综合征的治疗机制及效果

Therapeutic mechanism and efficacy of continuous blood purification for treatment of patients with acute respiratory distress syndrome

目的探讨连续性血液净化对急性呼吸窘迫综合征(ARDS)的治疗机制及效果。方法 25例ARDS患者作为对照组,采用一般常规治疗;另选取25例ARDS患者作为观察组,在一般治疗的基础上进行连续血液净化治疗。比较2组患者的临床治疗效果。结果观察组患者治疗后整体情况显著优于对照组(P<0.05);2组APACHEII评分在治疗后均有显著降低,其中观察组降低程度更为明显(P<0.05);治疗后观察组患者整体炎症因子水平显著低于对照组(P<0.05)。结论临床使用连续性血液净化治疗ARDS效果显著,能够有效改善患者呼吸状况、血流状况以及机体炎症因子水平,值得临床推广。

Objective To investigate the therapeutic mechanism and efficacy of continuous blood purification for treatment of patients with acute respiratory distress syndrome （ARDS）. Methods Twenty five ARDS patients were selected as control group and treated with conventional therapy. Another 25 ARDS patients were selected as observation group and treated with continuous blood purification on the basis of conventional therapy. Clinical effect was compared between two groups. Results After treatment, the overall situation of patients in the observation group was significantly better than those in the control group （P〈0.05）. After treatment, the APACHEII scores of the two groups decreased significantly, and the APACHEII score in the observation group decreased more significantly （P 〈 0.05 ）. After treatment, the inflammatory factor level in the observation group was significantly lower than that in the control group （ P 〈 0.05 ）. Conclusion Application of continuous blood purification can effectively treat acute respiratory distress syndrome in clinic, which can effectively improve the respiratory status of patients, blood flow and inflamma- tory cytokines, so it is worthy of clinical popularization.