阴道镜下多点活检联合LEEP术诊治宫颈上皮内瘤变的临床分析

Clinical analysis of colposcopy multi-points biopsy combined with LEEP surgery in the diagnosis and treatment of patients with cervical inner neoplasia

目的探讨阴道镜下多点活检联合LEEP术诊治宫颈上皮内瘤变的临床价值。方法选取89例宫颈上皮内瘤变患者,在阴道镜下多点活检后行LEEP术治疗,并做病理组织学诊断。观察患者的手术时间、术中出血量及治疗效果,比较两种方法取材的病理组织学诊断结果。结果 LEEP术的平均手术时间(7.23±2.91)min,术中出血量<25 m L,临床治愈率为86.52%。病理组织学诊断结果显示,与阴道镜下多点活检比较,LEEP术的炎症检出率较低,差异有统计学意义(P<0.05);宫颈上皮内瘤变的检出率较高。结论根据阴道镜活检结果,针对性使用LEEP术对诊治宫颈上皮内瘤变具有较好临床效果,值得推广应用。

Objective To investigate the clinical value of colposcopy multi-points biopsy combined with LEEP in the diagnosis and treatment of patients with cervical inner neoplasia. Methods A total o{ 89 patients with cervical inner neoplasia were treated with LEEP surgery after colposcopy multi-points biopsy, and the diagnosis for histopathology was performed. Operation time, intra- operative bleeding and effects were observed, and results of the diagnosis for histopathology by two methods were compared. Results For the LEEP surgery, the average operation time was （7.23± 2.91） minutes, intra-operative bleeding was less than 25 mL, and the ef- fective rate was 86.52 %. The histopathological diagnosis results showed that a lower detection rate of inflammatory was observed in LEEP surgery when compared with the colposcopy multi-points biopsy, and there was significant difference （P 〈 0.05）. A higher detection rate of CIN was ob- served in LEEP surgery. Conclusion Based on colposcopy and biopsy results, targeted application of LEEP is effective in diagnose and treatment of patients with cervical inner neoplasia, so it is worthy of popularization