十二指肠间质瘤的危险因素

Risk factors for duodenal gastrointestinal stromal tumors

背景：由于十二指肠间质瘤的发病率较低，所以其危险因素尚不可知。目的：探索十二指肠间质瘤的临床病理特征及手术治疗方法。方法：回顾性分析青岛大学附属医院2005年4月至2014年11月收治的28例十二指肠间质瘤资料。结果与结论：十二指肠问质瘤患者的1，3，5年生存率分别为92％，80％和72％。肿瘤大小、核分裂数与肿瘤破裂是独立的预后因素。根治性切除是最有效的治疗方法。伊马替尼可有效改善高复发风险患者的预后。

BACKGROUND ： The incidence of duodenum stromal tumor rate is relatively low, so the risk factor is unknown. OBJECTIVE： To investigate the clinical pathological features and surgical treatment of duodenal gastrointestinal stremal tumors. METHODS： Clinical data from 28 patients with duodenal gastrointestinal stromal tumors surgically managed from April 2005 to November 2014 in the Affiliated Hospital of Qingdao University were retrospectively studied. RESULTS AND CONCLUSION： The 1-, 3-, and 5- year overall survivals were 92%, 80%, and 72%, respectively. Tumor size, mitotic count, and tumor rupture were independent prognostic factors. Radical resection is the most effective treatment. Imatinib can effectively improve the prognosis of patients with high recurrence risk.