脑梗死患者血浆同型半胱氨酸水平与脑动脉狭窄的相关性分析

Correlation analysis of serum homocysteine and cerebral artery stenosis in cerebral infarction patients

目的：探讨脑梗死患者血浆同型半胱氨酸（Hcy）水平与脑动脉狭窄的相关性。方法回顾性分析165例经选择性全脑血管造影检查住院治疗的脑梗死患者的临床资料，根据 Hcy 水平分为三组，5．0～15．0μmol／L 组、15．1～20．0μmol／L 组、20．1μmol／L 以上组，记录患者的年龄、性别、血压、血脂、血糖等指标，记录颅内外脑血管狭窄的数目，分析判定 Hcy 水平与脑动脉狭窄是否具有相关性。结果165例脑梗死患者，血浆 Hcy 5．0～15．0μmol／L 组74例（45．18％），颅内外狭窄的血管共36条；15．0～20．0μmol／L 组50例（30．12％），颅内外狭窄的血管共66条；20．1μmol／L 以上组41例（24．70％），颅内外狭窄的血管共67条。各组血管狭窄的条数差异有统计学意义（F ＝4．12，P ＜0．05）。结论脑梗死患者血浆 Hcy 水平升高者比例大于 Hcy 水平正常者；随着 Hcy 水平的升高，颅内外血管动脉粥样硬化的程度呈加重趋势。

Objective To analyze the relationship between the level of serum homocysteine and cerebral artery stenosis in cerebral infarction patients.Methods Clinical data from 165 cerebral infarction patients who had been done cerebral angiography examination were analyzed.According to the level of serum homocysteine,the patients were divided into 5.0-15.0 μmol/L group,15.1-20.0 μmol/L group and above 20.1 μmol/L group.Other risk fac-tors including age,gender,blood pressure,blood lipid and blood glucose were recorded.The number of cerebral vascu-lar stenosis in different parts of brain were analyzed,and then make a decision of the relationship between the level of serum homocysteine and cerebral artery stenosis,as well as the other risk factors.Results Among 165 cases,74 cases （48.15%）came from 5.0-15.0 μmol/L group and the number of stenosal cerebral vascular was 36strips,50 cases （30.12%）came from 15.0-20.0 μmol/L group and the number of stenosal cerebral vascular was 66 strips,41 cases （24.70%）came from above 20.1 μmol/L group and the number of stenosal cerebral vascular was 67.Analysis of variance was conducted between the numbers of stenosal cerebral vascular of each group,the differences were significant （F =4.12,P 〈0.05）.Conclusion In cerebral infarction patients,the incidence of Hcy（hyperhomocysteinemia） was higher than that of normal hcy.2.shows more serious damage of intracranial and extracranial arterial sclerosis occur in patients with the increase of homocysteine levels.