血清同型半胱氨酸、光抑素C水平与2型糖尿病大血管并发症的关系研究

Correlations of serum Hcy, Cys C levels and type 2 diabetic macrovascular complications and its clinical sig- nificance

目的：探讨血清同型半胱氨酸（Hcy）和光抑素 C（Cys C）与2型糖尿病（T2DM）大血管并发症的的关系及临床意义。方法采用免疫比浊法测定量检测80例 T2DM大血管并发症患者（大血管病组）、80例无大血管并发症的 T2DM患者（无大血管病组）血清 Hcy 和 Cys C 浓度，并以80例健康人作为对照组。结果T2DM大血管病组 Hcy 和 Cys C 浓度分别为（26．42±5．75）μmol／L、（2．30±0．40）μmol／L，均高于无大血管病组的（15．31±3．13）μmol／L、（1．51±0．27）μmol／L（t ＝15．17、14．64，均 P ＜0．05）和对照组的（8．86±1．62）μmol／L、（0．85±0．14）μmol／L（t ＝26．29、30．56，均 P ＜0．05），无大血管病组血清 Hcy 和 Cys C 浓度高于对照组（t ＝16．37、19．36，均 P ＜0．05）；大血管病组有颈动脉增厚组 Hcy 和 Cys C 浓度分别为（32.53±6.46）μmol／L、（2．83±0．52）μmol／L，均高于无颈动脉增厚组的（18．46±3．63）μmol／L、（1．65±0.30）μmol／L （t ＝11．64、12．06，均 P ＜0．05）相关分析显示，血清 Hcy 和 Cys C 水平呈正相关（r ＝0．617，P ＜0.05）。结论Hcy 和 Cys C 可能与 T2DM大血管并发症发生发展有关，可作为监测及诊断 T2DM大血管病变有价值的参考指标，可能是 T2DM患者的重要独立危险因素之一。

Objective To explore the relation between serum Hcy,Cys C levels and type2 diabetic macro-vascular complications and its clinical significance.Methods The serum levels of Hcy and Cys C were measured with immunoturbidimetry in 80 cases of type 2 diabetic patients with macrovascular complications and 80 cases of type 2 diabetes without macrovascular complications,and in 80 healthy subjects which was seleted as control.Results Serum levels of Hcy and Cys C of type 2 diabetic patients with macrovascular complications were （26.42 ± 5.75）μmol/L and （2.30 ±0.40）μmol/L,which were higher than those of patients without macrovascular complica-tions for （15.31 ±3.13）μmol/L and （1.51 ±0.27）μmol/L（t =15.17,14.64,all P 〈0.05）;Moreover,which were also higher than those in the healthy control group for （8.86 ±1.62）μmol/L and （0.85 ±0.14）μmol/L（t =26.29, 30.56,all P 〈0.05）.The serum levels of Hcy and Cys C of type 2 diabetic patients with carotid arteries increased were （32.53 ±6.46）μmol/L and （2.83 ±0.52）μmol/L,which were higher than those of patients without carotid arteries for （18.46 ±3.63）μmol/L and （1.65 ±0.30）μmol/L（t =11.64,12.06,all P 〈0.05）.In patients of type 2 diabetic with macrovascular complications,Hcy was positively correlated with serum Cys C（r =0.617,P 〈0.05）. Conclusion sCD40L and YKL -40 may have important role in the pathogenesis of type 2 diabetic patients with ma-crovascular complications,which can be used as a valuable reference target in the diagnosis and monitoring of vascular complications in elderly type 2 diabetes,and it may be one of the important independent risk factors of patients with type 2 diabetes.