2013年辽宁省手足口病病原监测结果分析

Etiological analysis of hand-food-mouth disease in Liaoning in 2013

目的深入分析2013年辽宁省手足口病例的病原监测资料,掌握本地区病原分布特征及影响监测结果的因素。方法收集辽宁地区手足口病例样本的核酸检测资料,应用描述流行病学方法进行分析,地区分布则采用系统聚类分析,根据离差平方和法进行判定。结果 2013年辽宁省手足口病的病原分布以其他肠道病毒为主,病原谱具有地区差异。1~6岁年龄组的病原构成决定本地区的病原谱。在采样至检测时间〉28d的条件下,发病至采样时间与样本阳性检出率呈负相关（r=-0.770,P〈0.05）。结论手足口病病原监测以1~6岁年龄组为主要对象,根据实际情况尽量采集病例发病7d内的样本,采样至检测的时间〈28d的阳性检出效果较好。

Objective To understand the pathogenic feature of hand-foot-mouth disease（HFMD）in Liaoning,and to discuss its influencing factors. Methods Data of nucleic acid detection of HFMD in Liaoning province were collected to conduct a descriptive epidemiological analysis,and system cluster analysis was performed to show the regional distribution based on the sum of deviation square method. Results In 2013,the major pathogen of HFMD in Liaoning was found to be other enteroviruses,and varied in different regions.The pathogenic spectrum in the region was usually determined by the pathogen found in children of 1to 6years old.Spearman correlation analysis showed that the positive rate of samples was related to the sampling time if the sampling-detection internal was shorter than 28days（r=-0.770,P〈0.05）. Conclusions Children of1 to 6years old should be monitored intensively for the pathogen of HFMD which usually determines the pathogenic spectrum of a region.Sampling should be performed within 7days of disease onset and the interval between sampling and detection should be less than 28 days in order to achieve higher positive rate.