六所医院临床分离大肠埃希菌与肺炎克雷伯菌耐药性调查

Investigation on drug resistance of Escherichia coli and Klebsiella pneumoniae isolated from clinical samples in 6 hospitals

目的了解荆门地区医院临床分离大肠埃希菌和肺炎克雷伯菌耐药性情况,为临床用药提供参考。方法采用回顾性调查方法,对湖北荆门地区6所综合医院临床标本中分离的大肠埃希菌和肺炎克雷伯菌感染分布及耐药性进行统计分析。结果该地区6所医院连续2年共检出大肠埃希菌2 277株,其中产超广谱β-内酰胺酶菌株占51.12%;检出肺炎克雷伯菌854株,其中产超广谱β-内酰胺酶菌株占35.71%。两种细菌对临床常用抗菌药物普遍耐药,仅对碳青霉烯类抗菌药物敏感。β-内酰胺酶阳性菌株耐药率高于β-内酰胺酶阴性菌株。结论该地区医院分离大肠埃希菌和肺炎克雷伯菌中产超广谱β-内酰胺酶菌株比例较高,耐药性也比较高,提示该地区应加强耐药性的监测和提高药敏试验率。

Objective To investigate the drug resistance rate of Escherichia coli and Klebsiella pneumoniae in Jingmen, and provide evidence for clinic. Methods Retrospective investigation was used to analyze distribution and drug resistance rate of E. coli and K. pneumoniae isolated from clinical samples collected among 6 general hospitals of Jingmen . Results A total of 2 277 strain of E. coli and 854 strain of K. pneumoniae were collected from 6 hospitals,the prevalence rate of ex-tend-spectrumβ-lactamases（ ESBLs）was 51. 12% and 35. 71% for E. coli and K. pneumoniae. respectively. E. coli and K. pneumoniae were resistance to most of antibiotics,only sensitive to carbapenem,the resistance rate of ESBLs-posi-tive strains was higher than that of ESBLs-negative strains. Conclusion Proportion of ESBLs-positive for E. coli and K. pneumoniae isolated from hospital of this region and the antibiotics rate were high. It suggests that resistance monitoring and antibiotics test should be strengthen.