发酵冬虫夏草菌粉治疗早期糖尿病肾病临床观察

Clinical observation of Cordyceps sinensis on treating early diabetic nephropaty

目的观察发酵冬虫夏草菌粉治疗早期糖尿病肾病的临床效果。方法将早期糖尿病肾病患者67例随机分为2组,对照组32例给予常规治疗,治疗组35例在常规治疗基础上加用发酵冬虫夏草菌粉,治疗12周,比较2组治疗前后空腹血糖(fasting plasma glucose,FPG)、餐后2h血糖(postprandial two-hour plasma glucose,2hPG)、糖化血红蛋白(hemoglobin A1c,HbA1c)、尿微量白蛋白肌酐比值(urinary albumin-to-creatinine ratio,ACR)以及肾功能的变化。结果与治疗前比较,2组治疗后FPG、2hPG、HbA1c均明显降低(P<0.05),但治疗后2组间差异无统计学意义。与对照组比较,治疗组治疗后尿ACR明显降低,其差异有统计学意义(P<0.05)。结论发酵冬虫夏草菌粉能减少尿微量白蛋白,对早期糖尿病肾病有较好的治疗效果。

Objective To observe the effect of Cordyceps sinensis cultivated by artificial fermentation on early diabetic nephropathy.Methods Sixty-seven patients with early diabetic nephropathy were divided into two groups randomly,therapy group and control group.The patients in control group were given conventional therapy,while those in therapy group were given Cordyceps sinensis cultivated by artificial fermentation on the basis of therapy of control group.After 12 weeks′treatment,fasting plasma glucose（FPG）,the postprandial two-hour plasma glucose（2hPG）,hemoglobin A1c（HbA1c）,urinary albumin-to-creatinine ratio（ACR）and renal function were compared.Results After treatment,FPG,2hPG,and HbA1 c in therapy group and control group were improved as compared with before treatment（P〈0.05）,however,there were no significant differences after treatment between two groups.Compared with control group,the level of urine ACR in therapy group was significantly decreased as compared with control group（P〈0.05）.Conclusion Cordyceps sinensis cultivated by artificial fermentation can reduce urine albumin of patients with diabetic nephropathy,the clinical effect is satisfactory.