苄星青霉素、普鲁卡因青霉素与头孢曲松治疗早期梅毒疗效评价

Assessment of efficacy of benzathine penicillin,procaine penicillin and ceftriaxone in the treatment of early syphilis

目的:比较苄星青霉素、普鲁卡因青霉素及头孢曲松治疗早期梅毒的疗效。方法:102例首诊早期梅毒患者随机分为苄星青霉素组、普鲁卡因青霉素组及头孢曲松组,观察患者临床症状和血清RPR的变化。结果:苄星青霉素有效率92.68%、普鲁卡因青霉素93.93%、头孢曲松92.85%,三组之间比较无显著性差异(P>0.05),苄星青霉素组、普鲁卡因青霉素组和头孢曲松组血清固定分别占26.83%、20.00%和19.35%,三组比较差异有统计学意义(P<0.05)。结论:三种药物治疗早期梅毒疗效相当,但普鲁卡因青霉素组和头孢曲松组血清固定者明显低于苄星青霉素组。

Objective：To compare the efficacy of benzathine penicillin, procaine penicillin and ceftriaxone in the treatment of early syphilis. Methods： One hundred and two patients were divived into three groups：benzathine penicillin group （41 cases）, procaine penicillin group （33 cases） and ceftriaxone group （28 ca-ses） . The clinical efficacy and antibody in serum were assessed. Results：The efficiency rate in the benzathine penicillin group, procaine penicillin group, and the ceftriaxone group was 92.68%, 93.93% and 92.85% re-spectively. The negative conversion rates benzathine penicillin group, procaine penicillin group and ceftriaxone group were 26.83%, 20.00% and 19.35% respectively. Conclusion：The total efficaly of the three regiments is smiilar in the treatment of early syphilis. However, the proportion of the patients ivith sero-resistence was lower in procaine penicillin group and ceftriaxone group.