凋亡诱导因子AIF在pSS患者唇腺中的异常表达

Abnormal expression of AIF in the labial gland of patients with primary Sjogren's syndrome

目的研究凋亡诱导因子AIF在原发性干燥综合征患者唇腺中的表达水平及其作用。方法临床收集原发性干燥综合征患者唇黏膜(40例),以正常唇黏膜作对照(10例),采用免疫组化的方法检测两组唇腺组织中AIF蛋白的表达,记录积分吸光度值,采用统计学软件对积分吸光度值与临床检验结果进行相关性分析。结果正常唇黏膜AIF低表达,原发性干燥综合征患者唇腺组织中AIF的表达较正常唇黏膜明显增加(P<0.05),且与疾病的病程呈正相关,并随淋巴细胞浸润灶数的增加,表达呈增高趋势(P<0.05),但与其他临床特征之间相关性不明显。结论AIF在原发性干燥综合征患者唇腺组织中高表达,且与病理分级和疾病的病程相关。

Objective To study the expression of AIF in the labial glands of patients with primary Sjogren＇s syndrome（p SS）. Methods Forty patients with pathologically primary SS were investigated.Labial salivary gland tissue was examined for the expression of AIF by immunohistochemical analysis.Ten sex and age-matched healthy subjects were served as normal controls IOD was measured.The correlation between the clinical manifestations and the IOD of AIF were analyzed. Results The expression of AIF in p SS was significantly higher than those in control group（P〈0.05）. There was a positive correlation between the lymphocyte focus score and the expression of AIF,but has no correlation with the other clinical manifestations. Conclusion The expression of AIF is significantly increased in labial salivary glands in patients of p SS,which was related to the disease course and the lymphocyte focus score.