FoxO1蛋白在大肠腺癌组织中的表达及其临床意义

Expression of Fox O1 Protein in Large Intestinal Adenocarcinoma Tissue, and its Clinical Significance

为探讨Fox01蛋白在大肠腺癌组织中的表达及其临床意义，应用免疫组化染色法（IHC）和荧光原位杂交技术（FISH）对48例大肠腺癌患者癌组织及癌旁组织中Fox01蛋白表达进行检测，并应用SPSS13．0软件进行统计分析。结果显示，IHC检测结果显示，FoxOl蛋白在大肠腺癌组织中阳性表达率（25．00％，12／48）明显低于癌旁组织（68．75％，33／48），P〈0．05。FISH检测结果显示，48例大肠腺癌组织中32例显示阳性。IHC与FISH检测结果基本一致，r=0．340，P〈0．05。结果表明，Fox01蛋白在大肠腺癌组织中表达减少或缺失，这可能是导致结肠腺癌发病的机制之一。

This study was to explore expression of Fox O1 protein in large intestinal adenocarcinoma tissue and its clinical significance, so used immunohistochemistry（IHC） and fluorescence in situ hybridization （FISH） to detect the expression of Fox O1 protein in large intestinal adenocarcinoma tissue and in the tissue around neoplasm sample from 48 patients, then the detected results were analyzed statistically by using SPSS 13.0 software.As results,IHC detection showed that positivity expression rate of Fox O1 protein in large intestinal adenocarcinoma tissue was significantly lower than that in the tissue around neoplasm （25. 00% ,12/48 vs 68.7% ,33/48, P〈0.05） ;FISH detection showed that 32 of 48 cases appeared positively in large intestinal adenocarcinoma tissue,i.e the both detection results were accorded basically（ r = 0.340, P〈0.05）.Results show that decreased or deletion expression of Fox O1 protein in adenocarcinoma tissue of large intestine could be one of the pathogenesis inducing carcinomatosis.