蒙药嘎日迪散对大鼠溃疡性结肠炎的作用

Role of Mongolian Medicine Garidisan on Rat Ulcerative Colitis

目的:探讨嘎日迪散对大鼠溃疡性结肠炎的作用.方法:采用免疫法复合TNBS诱导法制作溃疡性结肠炎模型,从宏观和微观评价嘎日迪散对大鼠溃疡性结肠炎的治疗效果.结果:动物疾病活动指数、结肠粘膜损伤指数、结肠粘膜镜下评分的结果显示,各给药组和模型组相比具有统计学意义,HE结果显示,模型组还存在典型的溃疡,各给药组粘膜修复良好.结论:嘎日迪散能有效治疗大鼠溃疡性结肠炎,其作用和阳性药柳氮磺吡啶及补脾益肠丸相当.

Objective：To investigate the treatment effect of garidisan on rat ulcerative colitis.Methods：The rat model of ulcerative colitis is induced by immune method and TNBS.From the macrography and microscopic evaluation identified the pharmacodynamics of garidisan on rats ulcerative colitis.Results：.Animal disease activity index,the colon mucosal damage index,histopathological score of treatment group showed statistical significance comparing with model group.The results of HE showed that there were still typical ulcer in model group,other treatment group mucosal repaired well.Conclusion：The garidisan can effectively cure the rat ulcerative colitis.its role is identical with positive drug sulfasalazine and Bupiyichang.