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中药马兜铃酸的肾毒性研究 被引量:11

Study on Nephrotoxicity of Aristolochic Acid in Traditional Chinese Medicine
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摘要 目的:探讨马兜铃酸的毒性作用机制、马兜铃酸肾病发病机制与原因。方法:本文对近年来国内外对于马兜铃酸导致马兜铃酸肾病发生、发展的最新研究进行总结。结果:含马兜铃酸成分中药,与马兜铃酸肾病的发生密切相关。结论:本文为防治马兜铃酸肾病提供参考意见。 This paper was aimed to discuss the mechanism of aristolchic acid toxicity, pathogenesis and possible causes of aristolchic acid nephropathy. Recent published studies both at home and abroad were summarized on the impact of aristolchic acid on the incidence and progression of aristolchic acid nephropathy. The results showed that traditional Chinese medicine(TCM) containing aristolchic acid was closely associated with the incidence of aristolchic acid nephropathy. It was concluded that the paper provided some suggestions on preventing aristolchic acid nephropathy.
出处 《世界科学技术-中医药现代化》 2015年第5期1095-1099,共5页 Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金 国家自然科学基金委面上项目(81273717):基于蛋白质组学方法的"癌毒"病机研究 负责人:吴勉华 国家自然科学基金委面上项目(81473608):基于micro RNA调控网络的消癌解毒方抗肿瘤作用机制研究 负责人:周红光 国家自然科学基金委面上项目(81373511):基于肿瘤微环境的"癌毒"病机的生物学基础研究 负责人:程海波 国家自然科学基金委青年基金(81102563):基于代谢组学技术的消癌解毒方抗癌机理研究 负责人:周红光 中华人民共和国教育部项目(20113237110001):基于代谢组学方法的"癌毒"病机研究 负责人:吴勉华 江苏省普通高校研究生科研创新计划省立项目(CXLX12_0572):消癌解毒方调控人肝癌SMMC-7721细胞凋亡相关基因表达的研究 负责人:李文婷
关键词 马兜铃酸 马兜铃酸肾病 肾毒性 进展 Aristolochic acid aristolchic acid nephropathy nephrotoxicity research progress
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参考文献32

  • 1Debelle F D, Vanherweghem J L, Nortier J L. Aristolochic acid nephropathy: a worldwide problem. Kidney Int, 2008, 74(2): 158-169.
  • 2张品杰,魏杰,章飞芳,顾江萍,申河清,梁鑫淼.中药材中4种马兜铃酸的检测方法研究[J].世界科学技术-中医药现代化,2013,15(1):131-136. 被引量:6
  • 3Balachandran P, Wei F, Lin R C, et al. Structure activity relationships of aristolochlc acid analogues:toxicity in cultured renal epithelial cells. Kidney lnt, 2005, 67(5):1797-1805.
  • 4王潇晗,张连学,郜玉钢,臧埔,周瑞.含马兜铃酸中药减毒的研究进展[J].中草药,2013,44(22):3241-3244. 被引量:20
  • 5雷荣辉,吴纯启,廖明阳.马兜铃酸致突变及致癌性研究进展[J].中国新药杂志,2007,16(2):114-117. 被引量:5
  • 6Hong Y T, Fu L S, Chung L H, et al. Faneoni' s syndrome, interstitial fibrosis and renal failure by aristoloehic acid in Chinese herbs. Pediatr Nephrol, 2006, 21(4):577-579.
  • 7Yang L, Li X, Wang H. Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis. Nephrol Dial Transplant, 2007, 22(2):445-456.
  • 8Leung E M K, Chan W. Noninvasive measurement of aristolochic acid- DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectromen'y: evidence for DNA repair by nucleotide-excision repair mechanisms. Murat Res, 2014, 766-767(5): 1-6.
  • 9王勇,邓晓春.马兜铃酸结构多样性及其复方毒性研究进展[J].中草药,2006,37(8). 被引量:7
  • 10Huang T C, Chen S M, Li Y C, et al. Increased renal semicarbazide- sensitive amine oxidase activity and methylglyoxal levels in aristolochic acid-induced nephrotoxicity. Life Sci, 2014, 114(1):4-11.

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