摘要
砷暴露可以引起肝损伤、肝纤维化和肝硬化,主要病理改变为肝细胞肿胀、变性、坏死及汇管区炎性细胞浸润和不同程度的纤维化.砷致肝纤维化的机制是多方面的,氧化应激损伤、炎症反应及肝纤维化形成相关的多种细胞因子参与了砷暴露肝纤维化的发生发展.
Arsenic exposure may cause liver injury,fibrosis and cirrhosis,and the main pathological changes include swelling,degeneration and necrosis of hepatocytes,inflammatory cell infiltration in portal area and different degrees of fibrosis.The mechanisms by which arsenic causes liver fibrosis are complicated.Many kinds of cytokines which are closely related to oxidative stress injury,inflammation and liver fibrosis participate in the development and progression of arsenic induced liver fibrosis.
出处
《世界华人消化杂志》
CAS
2015年第22期3505-3509,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30471592~~
关键词
砷
肝纤维化
机制
Arsenic
Hepatic fibrosis
Mechanism
