摘要
肝部分切除是广泛运用于治疗肝脏良恶性肿瘤、肝内胆管结石、肝外伤等疾病,肝移植是治疗终末期肝病的唯一有效方式,但缺血再灌注损伤是肝切除术及肝移植的主要制约因素之一,其病理生理过程复杂,如何有效减轻术中缺血再灌注损伤将有助于降低手术对肝脏功能的影响.本文就缺血再灌注损伤分期、发生机制、对肝脏的不良影响及预防措施的相关研究作一综述.
Liver resection is widely used in the treatment of benign and malignancy tumors of the liver,intrahepatic bile duct stones,liver trauma and other diseases,and liver transplantation is the only effective way to treat end-stage liver disease.However,ischemia-reperfusion injury is one of the main restricting factors of liver resection and liver transplantation,and effective control of intraoperative ischemiareperfusion injury will help to reduce the effects of surgery on the liver function.In this paper,we review the recent advances in research of ischemia-reperfusion injury in terms of staging,pathogenesis,adverse effects and preventive measures.
出处
《世界华人消化杂志》
CAS
2015年第22期3554-3559,共6页
World Chinese Journal of Digestology
基金
贵州省科学技术基金资助项目
No.黔科合J字LKZ[2011]26~~
关键词
肝
缺血再灌注损伤
机制
预防措施
Liver
Ischemia-reperfusion injury
Mechanism
Preventive measures
