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长链非编码RNA在结直肠癌中的表达与调控机制 被引量：1

Expression and regulation of long non-coding RNAs in colorectal cancer
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摘要 长链非编码RNA(long non-coding RNA,lnc RNA)的结构类似于m RNA,长度大于200个核苷酸,广泛存在于真核细胞的细胞核和细胞质中,但却几乎不能编码蛋白质.lncR NA参与了许多真核细胞的生物活动,可以在表观遗传学、转录及转录后水平调节基因表达,在人类的生长发育以及细胞凋亡分化等诸多方面有重要作用,其异常表达还与许多人类疾病和肿瘤的发生、发展密切相关,本文就lnc RNA在结直肠恶性肿瘤中的基因表达及调控机制等方面的最新进展作一综述. Long non-coding RNA（lncRNA） has a messenger RNA-like structure,greater than 200 nucleotides in length,and extensively existing in both the cytoplasm and nucleus.However,almost all lncRNAs cannot be transcribed into proteins.Increasing studies showed that lncRNAs participate in many eukaryotic activities,such as regulating the expression of genes at epigenetic,transcriptional and posttranscriptional levels,and regulating human growth and development,and also,cell apoptosis.Their aberrant expression is involved in many human diseases and tumorigenesis.This article reviews the latest results of lncRNAs in colorectal cancer with regards to their expression and regulation.
作者 姜鹤宇 邹健 于晓峰
机构地区 复旦大学附属华东医院消化内科
出处 《世界华人消化杂志》 CAS 2015年第22期3567-3575,共9页 World Chinese Journal of Digestology
关键词 长链非编码RNA 结直肠癌 肿瘤标志物 Long non-coding RNA Colorectal cancer Tumor biomarker
分类号 R735.34 [医药卫生—肿瘤]
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世界华人消化杂志
2015年 第22期

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